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Malcolm Tingle

Explore the profile of Malcolm Tingle including associated specialties, affiliations and a list of published articles. Areas
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Articles 13
Citations 77
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Recent Articles
1.
Kingston E, Tingle M, Bellissima B, Helsby N, Burns K
Xenobiotica . 2023 Dec; 54(1):26-37. PMID: 38108307
Clozapine is an effective atypical antipsychotic indicated for treatment-resistant schizophrenia, but is under-prescribed due to the risk of severe adverse drug reactions such as myocarditis.A mechanistic understanding of clozapine cardiotoxicity...
2.
Jeong S, Sheridan J, Bullen C, Newcombe D, Walker N, Tingle M
Xenobiotica . 2018 Dec; 49(11):1332-1337. PMID: 30526213
1. Cytisine, a partial agonist for the αβ-nAChR, is used as a smoking cessation medication. Cytisine's current dosing is complex and involves taking 1.5 mg several times a day. The...
3.
Jeong S, Sheridan J, Newcombe D, Tingle M
Xenobiotica . 2017 Nov; 48(12):1245-1248. PMID: 29168931
1. Cytisine is a plant alkaloid that is a partial agonist for the αβ -nAChRs and is used as an aid to smoking cessation. To date, there are no published...
4.
Chang H, Telang R, Sreebhavan S, Tingle M, Thorne P, Vlajkovic S
Biomed Res Int . 2017 Feb; 2017:8091462. PMID: 28194422
Noise-induced hearing loss (NIHL) is a global health problem affecting over 5% of the population worldwide. We have shown previously that acute noise-induced cochlear injury can be ameliorated by administration...
5.
Vlajkovic S, Chang H, Paek S, Chi H, Sreebhavan S, Telang R, et al.
Biomed Res Int . 2014 Sep; 2014:841489. PMID: 25243188
Unlabelled: We have previously shown that adenosine amine congener (ADAC), a selective A1 adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury. Here we demonstrate the dose-dependent rescue effects...
6.
Jeong S, Newcombe D, Sheridan J, Tingle M
Drug Test Anal . 2014 Sep; 7(6):475-82. PMID: 25231024
Cytisine, an α4 β2 nicotinic receptor partial agonist, is a plant alkaloid that is commercially extracted for use as a smoking cessation medication. Despite its long history of use, there...
7.
Schep L, Gee P, Tingle M, Galea S, Newcombe D
BMJ . 2014 Aug; 349:g5085. PMID: 25122194
No abstract available.
8.
Ravindran S, Hopkins B, Bova S, Tingle M
Environ Toxicol Pharmacol . 2011 Jul; 28(1):147-51. PMID: 21783995
Norbormide's species-selective lethality displays 150-fold and 40-fold more sensitivity to rats than mice and guinea pigs, respectively. Our previous study revealed marked inter-species differences in rate and route of metabolism...
9.
Ravindran S, Hopkins B, Bova S, Rennison D, Brimble M, Tingle M
Environ Toxicol Pharmacol . 2011 Jul; 27(1):144-8. PMID: 21783932
Differences between species in response to norbormide (NRB) may arise through differential pharmacodynamic and/or pharmacokinetic properties. We hypothesise that species-selectivity is at least partly determined by differences in metabolism based...
10.
Helsby N, Tingle M
Am J Hematol . 2011 Mar; 86(4):383-4. PMID: 21442647
No abstract available.