Malcolm J Low
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Explore the profile of Malcolm J Low including associated specialties, affiliations and a list of published articles.
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121
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Recent Articles
1.
Yu H, Chiang A, Rubinstein M, Low M
Mol Metab
. 2024 Jul;
87:101993.
PMID: 39025297
Objective: Proopiomelanocortin (POMC) neurons release potent anorexigenic neuropeptides, which suppress food intake and enhance energy expenditure via melanocortin receptors. Although the importance of central melanocortin in physiological regulation is well...
2.
Rojo D, Hael C, Soria A, de Souza F, Low M, Franchini L, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(18):e2322692121.
PMID: 38652744
Food intake and energy balance are tightly regulated by a group of hypothalamic arcuate neurons expressing the proopiomelanocortin ( gene. In mammals, arcuate-specific expression is driven by two -acting transcriptional...
3.
Eliason N, Martin L, Low M, Sharpe A
Neuropeptides
. 2022 Sep;
96:102289.
PMID: 36155088
Rationale: Obesity is a major health problem worldwide. An understanding of the factors that drive feeding behaviors is key to the development of pharmaceuticals to decrease appetite and consumption. Proopiomelanocortin...
4.
Shakya M, Gahlot S, Martin N, Arunagiri A, Martin M, Arvan P, et al.
Endocrinology
. 2022 Mar;
PMID: 35245347
PCSK1 encodes an enzyme required for prohormone maturation into bioactive peptides. A striking number of SNPs and rare mutations in PCSK1 are associated with a range of clinical phenotypes. Infants...
5.
Yu H, Rubinstein M, Low M
Elife
. 2022 Jan;
11.
PMID: 35044906
Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential to regulate food intake and energy balance. However, the ontogenetic transcriptional programs that specify the identity and functioning of these...
6.
Surbhi , Wittmann G, Low M, Lechan R
Mol Metab
. 2021 Jul;
53:101312.
PMID: 34329773
Objective: Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential regulators of energy balance. Selective loss of POMC production in these cells results in extreme obesity and metabolic comorbidities....
7.
Shakya M, Gahlot S, White A, Verchere C, Low M, Lindberg I
Endocrinology
. 2021 Mar;
PMID: 33693631
Pro-opiomelanocortin (POMC) neurons form an integral part of the central melanocortin system regulating food intake and energy expenditure. Genetic and pharmacological studies have revealed that defects in POMC synthesis, processing,...
8.
Na E, Lam D, Yokosawa E, Adams J, Olson D, Low M
PLoS One
. 2020 Dec;
15(12):e0244793.
PMID: 33382813
Enhancer redundancy has been postulated to provide a buffer for gene expression against genetic and environmental perturbations. While work in Drosophila has identified functionally overlapping enhancers, work in mammalian models...
9.
10.
Feinmesser M, Asa S, Kovacs K, Roos B, Low M
Endocr Pathol
. 2020 May;
3(1):39-46.
PMID: 32357631
Clonal cell lines producing corticotropin-releasing hormone (CRH) have been generated by transfection of the W2 rat medullary thyroid carcinoma (MTC) cell with a CRH-encoding CMV/ SV40 expression vector. Here, we...