Malcolm Buckle
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Explore the profile of Malcolm Buckle including associated specialties, affiliations and a list of published articles.
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42
Citations
622
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Recent Articles
1.
Stander S, Reboul C, Le S, Williams D, Chandler P, Costa M, et al.
Nat Commun
. 2025 Mar;
16(1):2275.
PMID: 40055307
The enzyme glutamate decarboxylase (GAD) produces the neurotransmitter GABA, using pyridoxal-5'-phosphate (PLP). GAD exists as two isoforms, GAD65 and GAD67. Only GAD65 acts as a major autoantigen, frequently implicated in...
2.
Hatakeyama A, Shymko Y, Hartmann B, Retureau R, Nogues C, Pasi M, et al.
PLoS One
. 2022 Jul;
17(7):e0267382.
PMID: 35830437
Structural fluctuations of nucleosomes modulate the access to internal DNA in eukaryotic cells; clearly characterisation of this fundamental process is crucial to understanding gene regulation. Here we apply PhAST (Photochemical...
3.
Laszewski H, Palpant B, Buckle M, Nogues C
ACS Appl Bio Mater
. 2022 Jan;
4(6):4753-4759.
PMID: 35007025
Gold nanorods (GNRs) can be functionalized with multiple biomolecules allowing efficient cell targeting and delivery into specific cells. However, various issues have to be addressed prior to any clinical applications....
4.
Chandler P, Tan L, Porebski B, Green J, Riley B, Broendum S, et al.
J Biol Chem
. 2021 Feb;
296:100447.
PMID: 33617878
The fibronectin type III (FN3) monobody domain is a promising non-antibody scaffold, which features a less complex architecture than an antibody while maintaining analogous binding loops. We previously developed FN3Con,...
5.
Buckle A, Buckle M
Front Mol Biosci
. 2019 Dec;
6:123.
PMID: 31803754
In addition to the canonical loss-of-function mutations, mutations in proteins may additionally result in gain-of-function through the binary activation of cryptic "structural capacitance elements." Our previous bioinformatic analysis allowed us...
6.
Hayat Z, Bchellaoui N, Deo C, Metivier R, Bogliotti N, Xie J, et al.
Biosensors (Basel)
. 2019 Nov;
9(4).
PMID: 31683751
In this work, we report on the development of a newly synthesized photoactive reversible azobenzene derived surfactant polymer, which enables active and fast control of the merging of microdroplets in...
7.
Li C, Clark L, Zhang R, Porebski B, McCoey J, Borg N, et al.
J Mol Biol
. 2018 Aug;
430(18 Pt B):3200-3217.
PMID: 30111491
Canonical mechanisms of protein evolution include the duplication and diversification of pre-existing folds through genetic alterations that include point mutations, insertions, deletions, and copy number amplifications, as well as post-translational...
8.
Brach K, Hatakeyama A, Nogues C, Olesiak-Banska J, Buckle M, Matczyszyn K
Sci Rep
. 2018 Mar;
8(1):4528.
PMID: 29540820
The anisotropic shape of DNA molecules allows them to form lyotropic liquid crystals (LCs) at high concentrations. This liquid crystalline arrangement is also found in vivo (e.g., in bacteriophage capsids,...
9.
Hatakeyama A, Hartmann B, Travers A, Nogues C, Buckle M
Sci Rep
. 2016 Jun;
6:27337.
PMID: 27263658
We describe a biophysical approach that enables changes in the structure of DNA to be followed during nucleosome formation in in vitro reconstitution with either the canonical "Widom" sequence or...
10.
Zghidi-Abouzid O, Herault E, Rimsky S, Reverchon S, Nasser W, Buckle M
Res Microbiol
. 2016 Feb;
167(4):247-253.
PMID: 26912324
Dickeya dadantii is a pathogen infecting a wide range of plant species. Soft rot, the visible symptom, is mainly due to production of pectate lyases (Pels) that can destroy plant...