Maksym I Harhun
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Explore the profile of Maksym I Harhun including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
323
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Recent Articles
1.
Harhun M, Sukhanova K, Gordienko D, Dyskina Y
Pharmacol Rep
. 2015 Oct;
67(6):1055-60.
PMID: 26481522
Background: Purinergic P2X receptors in vascular smooth muscle cells (VSMCs) play an important role in physiological stimulatory responses to the extracellularly released ATP. The aim of this work was to...
2.
Harhun M
Cell Calcium
. 2015 Jun;
58(3):325-9.
PMID: 26104918
Vasomotion is the rhythmical changes in vascular tone of various blood vessels. It was proposed that in rabbit portal vein (RPV) the spontaneous contractile activity is driven by vascular interstitial...
3.
ATP-evoked sustained vasoconstrictions mediated by heteromeric P2X1/4 receptors in cerebral arteries
Harhun M, Povstyan O, Albert A, Nichols C
Stroke
. 2014 Jul;
45(8):2444-50.
PMID: 25070962
Background And Purpose: Current knowledge states that vasoconstrictor responses to ATP are mediated by rapidly desensitizing ligand-gated P2X1 receptors in vascular smooth muscle cells (VSMCs). However, ATP is implicated in...
4.
Sukhanova K, Thugorka O, Bouryi V, Harhun M, Gordienko D
Pharmacol Rep
. 2014 Jun;
66(3):363-72.
PMID: 24905510
Background: ATP is one of the principal sympathetic neurotransmitters which contracts vascular smooth muscle cells (SMCs) via activation of ionotropic P2X receptors (P2XRs). We have recently demonstrated that contraction of...
5.
Nichols C, Povstyan O, Albert A, Gordienko D, Khan O, Vasilikostas G, et al.
Purinergic Signal
. 2014 May;
10(4):565-72.
PMID: 24845338
Stimulation of P2X receptors by ATP in vascular smooth muscle cells (VSMCs) is proposed to mediate vascular tone. However, understanding of P2X receptor-mediated actions in human blood vessels is limited,...
6.
Sukhanova K, Harhun M, Bouryi V, Gordienko D
Pharmacol Rep
. 2013 Apr;
65(1):152-63.
PMID: 23563033
Background: There is growing evidence suggesting involvement of L-type voltage-gated Ca2+ channels (VGCCs) in purinergic signaling mechanisms. However, detailed interplay between VGCCs and P2X receptors in intracellular Ca2+ mobilization is...
7.
Huggins C, Povstyan O, Harhun M
Cell Tissue Res
. 2012 Dec;
352(2):265-75.
PMID: 23263463
Various in vitro models are used for studying phenotypic modulation of vascular smooth muscle cells (VSMCs) and the established culture of vascular smooth muscle cells (cVSMCs) is most often used...
8.
Harhun M, Huggins C, Ratnasingham K, Raje D, Moss R, Szewczyk K, et al.
J Cell Mol Med
. 2012 Aug;
16(11):2802-12.
PMID: 22862785
Vascular interstitial cells (VICs) are non-contractile cells with filopodia previously described in healthy blood vessels of rodents and their function remains unknown. The objective of this study was to identify...
9.
Jepps T, Chadha P, Davis A, Harhun M, Cockerill G, Olesen S, et al.
Circulation
. 2011 Jul;
124(5):602-11.
PMID: 21747056
Background: Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is...
10.
Povstyan O, Harhun M, Gordienko D
Br J Pharmacol
. 2010 Dec;
162(7):1618-38.
PMID: 21175582
Background And Purpose: P2X receptors mediate sympathetic control and autoregulation of the renal circulation triggering contraction of renal vascular smooth muscle cells (RVSMCs) via an elevation of intracellular Ca(2+) concentration...