Magesh Muthu
Overview
Explore the profile of Magesh Muthu including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
268
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Recent Articles
1.
Venkatesh J, Muthu M, Singaravelu I, Cheriyan V, Sekhar S, Acharige N, et al.
Front Oncol
. 2024 May;
14:1376666.
PMID: 38756656
CARP-1, a perinuclear phospho-protein, regulates cell survival and apoptosis signaling induced by genotoxic drugs. However, kinase(s) phosphorylating CARP-1 and down-stream signal transduction events remain unclear. Here we find that CARP-1...
2.
Tumova S, Milacek M, Snajdr I, Muthu M, Tuma R, reha D, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(48):e2215541119.
PMID: 36409882
Juvenile hormones (JHs) control insect metamorphosis and reproduction. JHs act through a receptor complex consisting of methoprene-tolerant (Met) and taiman (Tai) proteins to induce transcription of specific genes. Among chemically...
3.
Venkatesh J, Sekhar S, Cheriyan V, Muthu M, Meister P, Levi E, et al.
J Biol Chem
. 2020 Feb;
295(11):3532-3552.
PMID: 32024692
NF-κB is a pro-inflammatory transcription factor that critically regulates immune responses and other distinct cellular pathways. However, many NF-κB-mediated pathways for cell survival and apoptosis signaling in cancer remain to...
4.
Muthu M, Kumar R, Syed Khaja A, Gilthorpe J, Persson J, Nordstrom A
Cancers (Basel)
. 2019 Dec;
11(12).
PMID: 31817360
Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that ablation conferred resistance to several anticancer drugs in specific cancer cell lines...
5.
Muthu M, Nordstrom A
Int J Mol Sci
. 2019 Mar;
20(6).
PMID: 30893889
Tumor cells exhibit a specialized metabolism supporting their superior ability for rapid proliferation, migration, and apoptotic evasion. It is reasonable to assume that the specific metabolic needs of the tumor...
6.
Sekhar S, Venkatesh J, Cheriyan V, Muthu M, Levi E, Assad H, et al.
Cancers (Basel)
. 2019 Feb;
11(2).
PMID: 30769864
Cell Cycle and Apoptosis Regulatory Protein (CARP-1/CCAR1) is a peri-nuclear phosphoprotein that regulates apoptosis via chemotherapeutic Adriamycin (doxorubicin) and a novel class of CARP-1 functional mimetic (CFM) compounds. Although Adriamycin...
7.
Cheriyan V, Alsaab H, Sekhar S, Venkatesh J, Mondal A, Vhora I, et al.
Oncotarget
. 2018 Jul;
9(51):29680-29697.
PMID: 30038713
Non-small cell lung cancers (NSCLC) account for 85% of all lung cancers, and the epidermal growth factor receptor (EGFR) is highly expressed or activated in many NSCLC that permit use...
8.
Cheriyan V, Alsaab H, Sekhar S, Stieber C, Kesharwani P, Sau S, et al.
Oncotarget
. 2017 Dec;
8(62):104928-104945.
PMID: 29285223
Current treatments for Renal Cell Carcinoma (RCC) include a combination of surgery, targeted therapy, and immunotherapy. Emergence of resistant RCCs contributes to failure of drugs and poor prognosis, and thus...
9.
Cheriyan V, Muthu M, Patel K, Sekhar S, Rajeswaran W, Larsen S, et al.
Oncotarget
. 2016 Oct;
7(45):73370-73388.
PMID: 27687593
Doxorubicin and Cisplatin are the frontline therapeutics for treatment of the triple negative breast cancers (TNBCs). Emergence of drug-resistance often contributes to failure of drugs and poor prognosis, and thus...
10.
Muthu M, Somagoni J, Cheriyan V, Munie S, Levi E, Ashour A, et al.
J Biomed Nanotechnol
. 2015 Oct;
11(9):1608-27.
PMID: 26485930
The triple negative breast cancer (TNBCs) and non-small cell lung cancers (NSCLCs) often acquire mutations that contribute to failure of drugs in clinic and poor prognosis, thus presenting an urgent...