Magda Budzowska
Overview
Explore the profile of Magda Budzowska including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
1276
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Recent Articles
1.
Wild T, Budzowska M, Hellmuth S, Eibes S, Karemore G, Barisic M, et al.
Cell Rep
. 2018 Nov;
25(9):2317-2328.e5.
PMID: 30485802
The multisubunit ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) is essential for mitosis by promoting timely degradation of cyclin B1. APC/C is tightly regulated by the spindle assembly checkpoint (SAC), which involves...
2.
Semlow D, Zhang J, Budzowska M, Drohat A, Walter J
Cell
. 2016 Oct;
167(2):498-511.e14.
PMID: 27693351
During eukaryotic DNA interstrand cross-link (ICL) repair, cross-links are resolved ("unhooked") by nucleolytic incisions surrounding the lesion. In vertebrates, ICL repair is triggered when replication forks collide with the lesion,...
3.
Dewar J, Budzowska M, Walter J
Nature
. 2015 Sep;
525(7569):345-50.
PMID: 26322582
Eukaryotic DNA replication terminates when replisomes from adjacent replication origins converge. Termination involves local completion of DNA synthesis, decatenation of daughter molecules and replisome disassembly. Termination has been difficult to...
4.
Budzowska M, Graham T, Sobeck A, Waga S, Walter J
EMBO J
. 2015 Jun;
34(14):1971-85.
PMID: 26071591
DNA interstrand cross-links (ICLs) are repaired in S phase by a complex, multistep mechanism involving translesion DNA polymerases. After replication forks collide with an ICL, the leading strand approaches to...
5.
Zhang J, Dewar J, Budzowska M, Motnenko A, Cohn M, Walter J
Nat Struct Mol Biol
. 2015 Feb;
22(3):242-7.
PMID: 25643322
DNA interstrand cross-links (ICLs) prevent strand separation during DNA replication and transcription and therefore are extremely cytotoxic. In metazoans, a major pathway of ICL repair is coupled to DNA replication,...
6.
Long D, Joukov V, Budzowska M, Walter J
Mol Cell
. 2014 Sep;
56(1):174-85.
PMID: 25219499
The tumor suppressor protein BRCA1 promotes homologous recombination (HR), a high-fidelity mechanism to repair DNA double-strand breaks (DSBs) that arise during normal replication and in response to DNA-damaging agents. Recent...
7.
Budzowska M, Kanaar R
Cell Biochem Biophys
. 2008 Nov;
53(1):17-31.
PMID: 19034694
During every S phase, cells need to duplicate their genomes so that both daughter cells inherit complete copies of genetic information. Given the large size of mammalian genomes and the...
8.
Modesti M, Budzowska M, Baldeyron C, Demmers J, Ghirlando R, Kanaar R
Mol Cell
. 2007 Nov;
28(3):468-81.
PMID: 17996710
Homologous recombination is essential for preserving genome integrity. Joining of homologous DNA molecules through strand exchange, a pivotal step in recombination, is mediated by RAD51. Here, we identify RAD51AP1 as...
9.
Hanada K, Budzowska M, Davies S, van Drunen E, Onizawa H, Beverloo H, et al.
Nat Struct Mol Biol
. 2007 Oct;
14(11):1096-104.
PMID: 17934473
Faithful duplication of the genome requires structure-specific endonucleases such as the RuvABC complex in Escherichia coli. These enzymes help to resolve problems at replication forks that have been disrupted by...
10.
Hanada K, Budzowska M, Modesti M, Maas A, Wyman C, Essers J, et al.
EMBO J
. 2006 Oct;
25(20):4921-32.
PMID: 17036055
Repair of interstrand crosslinks (ICLs) requires multiple-strand incisions to separate the two covalently attached strands of DNA. It is unclear how these incisions are generated. DNA double-strand breaks (DSBs) have...