Mads S Toustrup-Jensen
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Explore the profile of Mads S Toustrup-Jensen including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Arystarkhova E, Toustrup-Jensen M, Holm R, Ko J, Lee K, Feschenko P, et al.
J Biol Chem
. 2022 Dec;
299(1):102758.
PMID: 36462665
ATP1A3 encodes the α3 isoform of Na,K-ATPase. In the brain, it is expressed only in neurons. Human ATP1A3 mutations produce a wide spectrum of phenotypes, but particular syndromes are associated...
2.
Roenn C, Li M, Schack V, Forster I, Holm R, Toustrup-Jensen M, et al.
J Biol Chem
. 2018 Nov;
294(1):269-280.
PMID: 30409907
The cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS) syndrome is caused by the single mutation E818K of the α3-isoform of Na,K-ATPase. Here, using biochemical and...
3.
Holm R, Toustrup-Jensen M, Einholm A, Schack V, Andersen J, Vilsen B
Biochim Biophys Acta
. 2016 Sep;
1857(11):1807-1828.
PMID: 27577505
Na,K-ATPase creates transmembrane ion gradients crucial to the function of the central nervous system. The α-subunit of Na,K-ATPase exists as four isoforms (α1-α4). Several neurological phenotypes derive from α3 mutations....
4.
Einholm A, Nielsen H, Holm R, Toustrup-Jensen M, Vilsen B
J Biol Chem
. 2016 Mar;
291(20):10934-47.
PMID: 27013656
The molecular mechanism underlying PKA-mediated regulation of Na(+),K(+)-ATPase was explored in mutagenesis studies of the potential PKA site at Ser-938 and surrounding charged residues. The phosphomimetic mutations S938D/E interfered with...
5.
Toustrup-Jensen M, Einholm A, Schack V, Nielsen H, Holm R, Sobrido M, et al.
J Biol Chem
. 2013 Dec;
289(6):3186-97.
PMID: 24356962
The neurological disorders familial hemiplegic migraine type 2 (FHM2), alternating hemiplegia of childhood (AHC), and rapid-onset dystonia parkinsonism (RDP) are caused by mutations of Na(+),K(+)-ATPase α2 and α3 isoforms, expressed...
6.
Einholm A, Toustrup-Jensen M, Holm R, Andersen J, Vilsen B
J Biol Chem
. 2010 Jun;
285(34):26245-54.
PMID: 20576601
Rapid-onset dystonia parkinsonism (RDP), a rare neurological disorder, is caused by mutation of the neuron-specific alpha3-isoform of Na(+), K(+)-ATPase. Here, we present the functional consequences of RDP mutation D923N. Relative...
7.
Toustrup-Jensen M, Holm R, Einholm A, Schack V, Morth J, Nissen P, et al.
J Biol Chem
. 2009 May;
284(28):18715-25.
PMID: 19416970
The Na(+),K(+)-ATPase C terminus has a unique location between transmembrane segments, appearing to participate in a network of interactions. We have examined the functional consequences of amino acid substitutions in...
8.
Blanco-Arias P, Einholm A, Mamsa H, Concheiro C, Gutierrez-de-Teran H, Romero J, et al.
Hum Mol Genet
. 2009 Apr;
18(13):2370-7.
PMID: 19351654
The Na(+)/K(+)-ATPases are ion pumps of fundamental importance in maintaining the electrochemical gradient essential for neuronal survival and function. Mutations in ATP1A3 encoding the alpha3 isoform cause rapid-onset dystonia-parkinsonism (RDP)....
9.
Morth J, Poulsen H, Toustrup-Jensen M, Schack V, Egebjerg J, Andersen J, et al.
Philos Trans R Soc Lond B Biol Sci
. 2008 Oct;
364(1514):217-27.
PMID: 18957371
The Na+,K+-ATPase transforms the energy of ATP to the maintenance of steep electrochemical gradients for sodium and potassium across the plasma membrane. This activity is tissue specific, in particular due...
10.
Schack V, Morth J, Toustrup-Jensen M, Anthonisen A, Nissen P, Andersen J, et al.
J Biol Chem
. 2008 Aug;
283(41):27982-27990.
PMID: 18669634
A cytoplasmic nontransport K(+)/Rb(+) site in the P-domain of the Na(+), K(+)-ATPase has been identified by anomalous difference Fourier map analysis of crystals of the [Rb(2)].E(2).MgF(4)(2-) form of the enzyme....