Mackenzie J Pearson
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Explore the profile of Mackenzie J Pearson including associated specialties, affiliations and a list of published articles.
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13
Citations
448
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Recent Articles
1.
Yu X, Chen S, Funcke J, Straub L, Pirro V, Emont M, et al.
Cell Metab
. 2024 Dec;
37(1):187-204.e7.
PMID: 39642881
Obesity is a chronic disease that contributes to the development of insulin resistance, type 2 diabetes (T2D), and cardiovascular risk. Glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) and glucagon-like peptide-1 (GLP-1)...
2.
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris P, et al.
Sci Immunol
. 2024 Apr;
9(94):eadh2334.
PMID: 38669316
T cells are often absent from human cancer tissues during both spontaneously induced immunity and therapeutic immunotherapy, even in the presence of a functional T cell-recruiting chemokine system, suggesting the...
3.
Zhang Z, Singh M, Kindt A, Wegrzyn A, Pearson M, Ali A, et al.
J Chromatogr A
. 2023 Sep;
1708:464342.
PMID: 37696124
The importance of lipids seen in studies of metabolism, cancer, the recent COVID-19 pandemic and other diseases has brought the field of lipidomics to the forefront of clinical research. Quantitative...
4.
Eshima H, Shahtout J, Siripoksup P, Pearson M, Mahmassani Z, Ferrara P, et al.
Elife
. 2023 Mar;
12.
PMID: 36951533
Reactive oxygen species (ROS) accumulation is a cardinal feature of skeletal muscle atrophy. ROS refers to a collection of radical molecules whose cellular signals are vast, and it is unclear...
5.
Romsdahl T, Cocuron J, Pearson M, Alonso A, Chapman K
Front Plant Sci
. 2022 Nov;
13:1038161.
PMID: 36438089
The lipidome comprises the total content of molecular species of each lipid class, and is measured using the analytical techniques of lipidomics. Many liquid chromatography-mass spectrometry (LC-MS) methods have previously...
6.
Su B, Bettcher L, Hsieh W, Hornburg D, Pearson M, Blomberg N, et al.
J Am Soc Mass Spectrom
. 2021 Oct;
32(11):2655-2663.
PMID: 34637296
Differential mobility spectrometry (DMS) is highly useful for shotgun lipidomic analysis because it overcomes difficulties in measuring isobaric species within a complex lipid sample and allows for acyl tail characterization...
7.
Khan M, Codreanu S, Goyal S, Wages P, Gorti S, Pearson M, et al.
Rapid Commun Mass Spectrom
. 2020 Aug;
34(22):e8911.
PMID: 32738001
Rationale: The Lipidyzer platform was recently updated on a SCIEX QTRAP 6500+ mass spectrometer and offers a targeted lipidomics assay including 1150 different lipids. We evaluated this targeted approach using...
8.
Sharma A, Quittner-Strom E, Lee Y, Johnson J, Martin S, Yu X, et al.
Cell Rep
. 2018 Feb;
22(7):1760-1773.
PMID: 29444429
The antidiabetic potential of glucagon receptor antagonism presents an opportunity for use in an insulin-centric clinical environment. To investigate the metabolic effects of glucagon receptor antagonism in type 2 diabetes,...
9.
Hepler C, Shao M, Xia J, Ghaben A, Pearson M, Vishvanath L, et al.
Elife
. 2017 Jul;
6.
PMID: 28722653
Visceral adiposity confers significant risk for developing metabolic disease in obesity whereas preferential expansion of subcutaneous white adipose tissue (WAT) appears protective. Unlike subcutaneous WAT, visceral WAT is resistant to...
10.
Taylor O, Thatcher M, Carr S, Gibbs J, Trumbull A, Harrison M, et al.
Int J Mol Sci
. 2017 May;
18(5).
PMID: 28531105
We have previously found that cigarette smoke disrupts metabolic function, in part, by increasing muscle ceramide accrual. To further our understanding of this, we sought to determine the role of...