Mackenzie J Parker
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Explore the profile of Mackenzie J Parker including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
110
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0
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Recent Articles
1.
Parker M, Lee H, Yao S, Irwin S, Hwang S, Belanger K, et al.
Biochemistry
. 2023 Jul;
62(14):2147-2160.
PMID: 37403936
Werner syndrome protein (WRN) is a multifunctional enzyme with helicase, ATPase, and exonuclease activities that are necessary for numerous DNA-related transactions in the human cell. Recent studies identified WRN as...
2.
Lee Y, Dai N, Muller S, Guan C, Parker M, Fraser M, et al.
Nucleic Acids Res
. 2021 Sep;
50(6):3001-3017.
PMID: 34522950
The DNAs of bacterial viruses are known to contain diverse, chemically complex modifications to thymidine that protect them from the endonuclease-based defenses of their cellular hosts, but whose biosynthetic origins...
3.
Burke E, Rodda S, Lund S, Sun Z, Zeroka M, OToole K, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(26).
PMID: 34155108
TET/JBP (ten-eleven translocation/base J binding protein) enzymes are iron(II)- and 2-oxo-glutarate-dependent dioxygenases that are found in all kingdoms of life and oxidize 5-methylpyrimidines on the polynucleotide level. Despite their prevalence,...
4.
Soule J, Gnann A, Gonzalez R, Parker M, McKenna K, Nguyen S, et al.
Biochem Biophys Res Commun
. 2019 Nov;
522(1):107-112.
PMID: 31753487
Methyl sulfur compounds are a rich source of environmental sulfur for microorganisms, but their use requires redox systems. The bacterial sfn and msu operons contain two-component flavin-dependent monooxygenases for dimethylsulfone...
5.
Parker M, Weigele P, Saleh L
Biochemistry
. 2018 Dec;
58(6):450-467.
PMID: 30571101
A tight link exists between patterns of DNA methylation at carbon 5 of cytosine and differential gene expression in mammalian tissues. Indeed, aberrant DNA methylation results in various human diseases,...
6.
Parker M, Maggiolo A, Thomas W, Kim A, Meisburger S, Ando N, et al.
Proc Natl Acad Sci U S A
. 2018 May;
115(20):E4594-E4603.
PMID: 29712847
The high fidelity of DNA replication and repair is attributable, in part, to the allosteric regulation of ribonucleotide reductases (RNRs) that maintains proper deoxynucleotide pool sizes and ratios in vivo....
7.
Lin Q, Parker M, Taguchi A, Ravichandran K, Kim A, Kang G, et al.
J Biol Chem
. 2017 Apr;
292(22):9229-9239.
PMID: 28377505
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleoside diphosphate substrates (S) to deoxynucleotides with allosteric effectors (e) controlling their relative ratios and amounts, crucial for fidelity of DNA replication and...
8.
Huang M, Parker M, Stubbe J
J Biol Chem
. 2014 Aug;
289(41):28104-11.
PMID: 25160629
Over one-third of all proteins require metallation for function (Waldron, K. J., Rutherford, J. C., Ford, D., and Robinson, N.J. (2009) Nature 460, 823-830). As biochemical studies of most proteins...
9.
Parker M, Zhu X, Stubbe J
Biochemistry
. 2014 Jan;
53(4):766-76.
PMID: 24401092
The class Ib ribonucleotide reductase (RNR) isolated from Bacillus subtilis was recently purified as a 1:1 ratio of NrdE (α) and NrdF (β) subunits and determined to have a dimanganic-tyrosyl...