Maciej Giedyk
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Explore the profile of Maciej Giedyk including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
142
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Recent Articles
1.
Wincenciuk A, Cmoch P, Giedyk M, Andersson M, Gryko D
J Am Chem Soc
. 2024 Jul;
146(29):19828-19838.
PMID: 39003762
In recent years, methodologies that rely on water as the reaction medium have gained considerable attention. The unique properties of micellar solutions were shown to improve the regio-, stereo-, and...
2.
Potrzasaj A, Musiejuk M, Chaladaj W, Giedyk M, Gryko D
J Am Chem Soc
. 2021 Jun;
143(25):9368-9376.
PMID: 34081860
Ring-opening of epoxides furnishing either linear or branched products belongs to the group of classic transformations in organic synthesis. However, the regioselective cross-electrophile coupling of aryl epoxides with aryl halides...
3.
Santos M, Cybularczyk-Cecotka M, Konig B, Giedyk M
Chemistry
. 2020 Jul;
26(66):15323-15329.
PMID: 32614104
Aromatic heterocycles are omnipresent structural motifs in various natural products, pharmaceuticals and agrochemicals. This work describes a photocatalytic Minisci-type C-H functionalization of heteroarenes with non-activated alkyl bromides. The reaction avoids...
4.
Giedyk M, Jackowska A, Rownicki M, Kolanowska M, Trylska J, Gryko D
Chem Commun (Camb)
. 2018 Nov;
55(6):763-766.
PMID: 30480264
Specifically designed, antisense oligonucleotides are promising candidates for antibacterial drugs. They suppress the correct expression of bacterial genes by complementary binding to essential sequences of bacterial DNA or RNA. The...
5.
O Proinsias K, Jackowska A, Radzewicz K, Giedyk M, Gryko D
Org Lett
. 2017 Dec;
20(1):296-299.
PMID: 29272133
Vitamin B, a natural Co-complex, catalyzes atom transfer radical addition (ATRA) of organic halides to olefins. The established conditions were found to be very selective, with atom transfer radical polymerization...
6.
Giedyk M, Turkowska J, Lepak S, Marculewicz M, O Proinsias K, Gryko D
Org Lett
. 2017 Apr;
19(10):2670-2673.
PMID: 28453294
Vitamin B is a natural cobalt complex that, while reduced to the "supernucleophilic" Co(I) form, can easily react with electrophiles via an S2 mechanism. It is also shown to react...
7.
Giedyk M, Goliszewska K, O Proinsias K, Gryko D
Chem Commun (Camb)
. 2015 Dec;
52(7):1389-92.
PMID: 26618606
Cobalester, a natural nontoxic vitamin B12 derivative, was found to catalyse unusual olefinic sp(2) C-H alkylation with diazo reagents as a carbene source instead of the expected cyclopropanation.
8.
Giedyk M, Goliszewska K, Gryko D
Chem Soc Rev
. 2015 May;
44(11):3391-404.
PMID: 25945462
Vitamin B12 (cobalamin, 1) is one of a few naturally occurring organometallic molecules. As a cofactor for adenosylcobalamin-dependent and methylcobalamin-dependent enzymes, it plays a crucial role in biological processes, including...
9.
Giedyk M, O Proinsias K, Kurcon S, Sharina I, Martin E, Gryko D
ChemMedChem
. 2014 Jul;
9(10):2344-50.
PMID: 25044578
Specially designed B-ring-modified cobalamin derivatives were synthesized and tested as potential activators of soluble guanylyl cyclase (sGC). Herein, we disclose the influence of substituents at the c- and d-positions in...
10.
O Proinsias K, Giedyk M, Sharina I, Martin E, Gryko D
ACS Med Chem Lett
. 2014 Jun;
3(6):476-9.
PMID: 24900497
Herein, the synthesis of novel hydrophobic and hydrophilic cobinamides via aminolysis of vitamin B12 derivatives that activate soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators, they target the...