Maarten L Hekkelman
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Explore the profile of Maarten L Hekkelman including associated specialties, affiliations and a list of published articles.
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17
Citations
1191
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Recent Articles
1.
Agirre J, Atanasova M, Bagdonas H, Ballard C, Basle A, Beilsten-Edmands J, et al.
Acta Crystallogr D Struct Biol
. 2023 Jun;
79(Pt 6):449-461.
PMID: 37259835
The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective with a mission to develop, test, distribute and promote software for macromolecular crystallography. The CCP4 suite is a...
2.
Dialpuri J, Bagdonas H, Atanasova M, Schofield L, Hekkelman M, Joosten R, et al.
Acta Crystallogr D Struct Biol
. 2023 May;
79(Pt 6):462-472.
PMID: 37219590
The oligosaccharides in N-glycosylation provide key structural and functional contributions to a glycoprotein. These contributions are dependent on the composition and overall conformation of the glycans. The Privateer software allows...
3.
Varadi M, Nair S, Sillitoe I, Tauriello G, Anyango S, Bienert S, et al.
Gigascience
. 2022 Nov;
11.
PMID: 36448847
While scientists can often infer the biological function of proteins from their 3-dimensional quaternary structures, the gap between the number of known protein sequences and their experimentally determined structures keeps...
4.
Hekkelman M, de Vries I, Joosten R, Perrakis A
Nat Methods
. 2022 Nov;
20(2):205-213.
PMID: 36424442
Artificial intelligence-based protein structure prediction approaches have had a transformative effect on biomolecular sciences. The predicted protein models in the AlphaFold protein structure database, however, all lack coordinates for small...
5.
van Ruiten M, van Gent D, Sedeno Cacciatore A, Fauster A, Willems L, Hekkelman M, et al.
Nat Struct Mol Biol
. 2022 Jun;
29(6):586-591.
PMID: 35710836
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin's SMC3 subunit is a dynamic process that involves the...
6.
de Vries I, Kwakman T, Lu X, Hekkelman M, Deshpande M, Velankar S, et al.
Acta Crystallogr D Struct Biol
. 2021 Sep;
77(Pt 9):1127-1141.
PMID: 34473084
The quality of macromolecular structure models crucially depends on refinement and validation targets, which optimally describe the expected chemistry. Commonly used software for these two procedures has been designed and...
7.
Van Beusekom B, Damaskos G, Hekkelman M, Salgado-Polo F, Hiruma Y, Perrakis A, et al.
Acta Crystallogr D Struct Biol
. 2021 Jan;
77(Pt 1):28-40.
PMID: 33404523
Comparison of homologous structure models is a key step in analyzing protein structure. With a wealth of homologous structures, comparison becomes a tedious process, and often only a small (user-biased)...
8.
Sobolev O, Afonine P, Moriarty N, Hekkelman M, Joosten R, Perrakis A, et al.
Structure
. 2020 Aug;
28(11):1249-1258.e2.
PMID: 32857966
Ramachandran plots report the distribution of the (ϕ, ψ) torsion angles of the protein backbone and are one of the best quality metrics of experimental structure models. Typically, validation software...
9.
Francica P, Mutlu M, Blomen V, Oliveira C, Nowicka Z, Trenner A, et al.
Cell Rep
. 2020 Aug;
32(8):108068.
PMID: 32846126
Using genome-wide radiogenetic profiling, we functionally dissect vulnerabilities of cancer cells to ionizing radiation (IR). We identify ERCC6L2 as a major determinant of IR response, together with classical DNA damage...
10.
Morris C, Andreetto P, Banci L, Bonvin A, Chojnowski G, Del Cano L, et al.
J Struct Biol X
. 2020 Jul;
1:100006.
PMID: 32647812
The West-Life project (https://about.west-life.eu/) is a Horizon 2020 project funded by the European Commission to provide data processing and data management services for the international community of structural biologists, and...