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Maarit Valkealahti

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Articles 9
Citations 104
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Recent Articles
1.
Rytky S, Tiulpin A, Finnila M, Karhula S, Sipola A, Kurttila V, et al.
Ann Biomed Eng . 2024 Feb; 52(5):1255-1269. PMID: 38361137
Purpose: Clinical cone-beam computed tomography (CBCT) devices are limited to imaging features of half a millimeter in size and cannot quantify the tissue microstructure. We demonstrate a robust deep-learning method...
2.
Helynen N, Rantanen L, Lehenkari P, Valkealahti M
Arch Orthop Trauma Surg . 2022 Mar; 143(5):2261-2271. PMID: 35290501
Objective: The life-time risk of a second fragile hip fracture is 8.4%, but the risk factors that predispose to a second hip fracture remain unresolved. This study aimed to define...
3.
Abdelwahab A, Palosaari S, Abdelwahab S, Rifaai R, El-Tahawy N, Saber E, et al.
Autoimmunity . 2020 Dec; 54(1):23-34. PMID: 33377396
Toll-like receptors (TLRs) are known to have an important role in triggering the innate immune response and in priming antigen-specific adaptive immunity and inflammation. The differences in synovial tissue expression...
4.
Ylitalo T, Finnila M, Gahunia H, Karhula S, Suhonen H, Valkealahti M, et al.
J Orthop Res . 2019 Feb; 37(4):855-866. PMID: 30737811
One of the earliest changes in osteoarthritis (OA) is a surface discontinuity of the articular cartilage (AC), and these surface changes become gradually more complex with OA progression. We recently...
5.
Luukkonen J, Pascual L, Patlaka C, Lang P, Turunen S, Halleen J, et al.
PLoS One . 2017 Aug; 12(8):e0182904. PMID: 28792533
Background: Osteopontin (OPN) is an immunoregulatory protein which production increases in both rheumatoid arthritis (RA) and osteoarthritis (OA). Phosphorylated osteopontin (Phospho-OPN) is known to increase macrophage and osteoclast activation, this...
6.
Huhtakangas J, Veijola J, Turunen S, Karjalainen A, Valkealahti M, Nousiainen T, et al.
Data Brief . 2017 May; 12:593-602. PMID: 28540351
In this article, we share the raw cytokine data obtained from basal and stimulated synovial stromal cells cultured from patients with rheumatoid arthritis or osteoarthritis. This data article is related...
7.
Huhtakangas J, Veijola J, Turunen S, Karjalainen A, Valkealahti M, Nousiainen T, et al.
J Steroid Biochem Mol Biol . 2017 Feb; 173:13-22. PMID: 28167299
Objectives: We investigated the effects of 1,25-dihydroxy vitamin D (1,25(OH)D), i.e. biologically active vitamin D and calcipotriol, a vitamin D analog, on growth and secretion of inflammatory mediators in synovial...
8.
Turunen S, Huhtakangas J, Nousiainen T, Valkealahti M, Melkko J, Risteli J, et al.
Arthritis Res Ther . 2016 Oct; 18(1):239. PMID: 27765067
Background: Seropositive rheumatoid arthritis (RA) is characterized by autoantibodies binding to citrullinated and homocitrullinated proteins. We wanted to study the expression patterns of these disease-associated protein forms and if the...
9.
Finnila M, Thevenot J, Aho O, Tiitu V, Rautiainen J, Kauppinen S, et al.
J Orthop Res . 2016 May; 35(4):785-792. PMID: 27227565
Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in bone structure compared to cartilage degeneration. This study linked structural adaptation of...