Maaged Akiel
Overview
Explore the profile of Maaged Akiel including associated specialties, affiliations and a list of published articles.
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9
Citations
168
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Recent Articles
1.
Akiel M, Alsughayyir J, Basudan A, Alamri H, Dera A, Barhoumi T, et al.
Biol Pharm Bull
. 2021 Jan;
44(3):372-378.
PMID: 33431739
The prevalence of cancer-associated anemia (CIA) is high, and the mechanisms governing its development remain poorly understood. Eryptosis, the suicidal cell death of red blood cells (RBCs), may account for...
2.
Alamri H, Alsughayyir J, Akiel M, Al-Sheikh Y, Basudan A, Dera A, et al.
J Food Biochem
. 2020 Nov;
45(1):e13545.
PMID: 33145778
Chemotherapy-induced anemia (CIA) is a major obstacle in cancer management. Although the mechanisms governing CIA are poorly understood, recent efforts have identified suicidal erythrocyte (red blood cell, RBC) death as...
3.
Al Mahri S, Al Ghamdi A, Akiel M, Al Aujan M, Mohammad S, Aziz M
World J Gastrointest Oncol
. 2020 May;
12(5):514-525.
PMID: 32461783
Background: Colorectal cancer (CRC) is a worldwide problem, which has been associated with changes in diet and lifestyle pattern. As a result of colonic fermentation of dietary fibres, short chain...
4.
Akiel M, Guo C, Li X, Rajasekaran D, Mendoza R, Robertson C, et al.
Cancer Res
. 2017 Jun;
77(15):4014-4025.
PMID: 28619711
Activation of IGF signaling is a major oncogenic event in diverse cancers, including hepatocellular carcinoma (HCC). In this setting, the insulin-like growth factor binding protein IGFBP7 inhibits IGF signaling by...
5.
Akiel M, Rajasekaran D, Gredler R, Siddiq A, Srivastava J, Robertson C, et al.
J Hepatocell Carcinoma
. 2016 Aug;
1:9-19.
PMID: 27508172
Hepatocellular carcinoma (HCC) is a vicious and highly vascular cancer with a dismal prognosis. It is a life-threatening illness worldwide that ranks fifth in terms of cancer prevalence and third...
6.
Rajasekaran D, Srivastava J, Ebeid K, Gredler R, Akiel M, Jariwala N, et al.
Bioconjug Chem
. 2015 Jun;
26(8):1651-61.
PMID: 26079152
Hepatocellular carcinoma (HCC) is a fatal cancer with no effective therapy. Astrocyte elevated gene-1 (AEG-1) plays a pivotal role in hepatocarcinogenesis and inhibits retinoic acid-induced gene expression and cell death....
7.
Robertson C, Srivastava J, Siddiq A, Gredler R, Emdad L, Rajasekaran D, et al.
J Biol Chem
. 2015 Jun;
290(29):18227-18236.
PMID: 26070567
Astrocyte elevated gene-1 (AEG-1), also known as MTDH (metadherin) or LYRIC, is an established oncogene. However, the physiological function of AEG-1 is not known. To address this question, we generated...
8.
Robertson C, Srivastava J, Siddiq A, Gredler R, Emdad L, Rajasekaran D, et al.
Cancer Res
. 2014 Sep;
74(21):6184-93.
PMID: 25193383
Activation of the oncogene AEG-1 (MTDH, LYRIC) has been implicated recently in the development of hepatocellular carcinoma (HCC). In mice, HCC can be initiated by exposure to the carcinogen DEN,...
9.
Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, et al.
FEBS Open Bio
. 2014 Jun;
4:353-61.
PMID: 24918049
Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells. We now document that SND1 increases angiotensin II type 1...