M W Brechbiel
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Explore the profile of M W Brechbiel including associated specialties, affiliations and a list of published articles.
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118
Citations
1934
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Recent Articles
1.
Kurdziel K, Mena E, McKinney Y, Wong K, Adler S, Sissung T, et al.
J Transl Sci
. 2019 Mar;
5(2).
PMID: 30906574
Introduction: Tumors over-expressing the human epithelial receptor 2 (HER2) or exhibiting amplification or mutation of its proto-oncogene have a poorer prognosis. Using trastuzumab and/or other HER2 targeted therapies can increase...
2.
Guerard F, Navarro L, Lee Y, Roumesy A, Alliot C, Cherel M, et al.
Bioorg Med Chem
. 2017 Oct;
25(21):5975-5980.
PMID: 28964629
In this report we describe the development of an alternative approach to arylstannane chemistry for radiolabeling antibodies with radioiodine or astatine based on aryliodonium salts precursors. Bifunctional aryliodonium salts were...
3.
Guerard F, Beyler M, Lee Y, Tripier R, Gestin J, Brechbiel M
Dalton Trans
. 2017 Mar;
46(14):4749-4758.
PMID: 28338136
Three hydroxypyridinone (HOPO) positional isomers - 1,2-HOPO (L1H) and its water soluble analogue (L1'H), 3,2-HOPO (L2H) and 3,4-HOPO (L3H) have been investigated for the complexation of Zr(iv). Potentiometric and UV-Vis...
4.
Hay R, Casalino D, Kordylewski L, Atcher R, Brechbiel M, Gansow O, et al.
Cardiovasc Pathol
. 2015 May;
1(3):189-98.
PMID: 25990276
Nuclear imaging of atheromata must distinguish lesions from both blood pool and normal arterial tissue. We have examined spatial and temporal variations of indium-111-labeled human low density lipoprotein (LDL) accumulation...
5.
Yong K, Milenic D, Baidoo K, Brechbiel M
Br J Cancer
. 2013 May;
108(10):2013-20.
PMID: 23632482
Background: Paclitaxel has recently been reported by this laboratory to potentiate the high-LET radiation therapeutic (212)Pb-TCMC-trastuzumab, which targets HER2. To elucidate mechanisms associated with this therapy, targeted α-particle radiation therapeutic...
6.
Song H, Kang C, Baidoo K, Milenic D, Chen Y, Dai A, et al.
Bioconjug Chem
. 2011 May;
22(6):1128-35.
PMID: 21604692
A new bifunctional ligand 3p-C-DEPA was synthesized and evaluated for use in targeted α-radioimmunotherapy. 3p-C-DEPA was efficiently prepared via regiospecific ring opening of an aziridinium ion and conjugated with trastuzumab....
7.
Nwe K, Bernardo M, Regino C, Williams M, Brechbiel M
Bioorg Med Chem
. 2010 Jul;
18(16):5925-31.
PMID: 20663676
In this report we directly compare the in vivo and in vitro MRI properties of gadolinium-dendrimer conjugates of derivatized acyclic diethylenetriamine-N,N',N',N'',N''-pentaacetic acid (1B4M-DTPA) and macrocyclic 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (C-DOTA). The metal-ligand...
8.
Bumb A, Regino C, Perkins M, Bernardo M, Ogawa M, Fugger L, et al.
Nanotechnology
. 2010 Apr;
21(17):175704.
PMID: 20368682
Multi-modality imaging probes combine the advantages of individual imaging techniques to yield highly detailed anatomic and molecular information in living organisms. Herein, we report the synthesis and characterization of a...
9.
Regino C, Wong K, Milenic D, Holmes E, Garmestani K, Choyke P, et al.
Curr Radiopharm
. 2010 Jan;
2(1):9-17.
PMID: 20047017
Better tumor markers are needed for early diagnosis and staging of prostate cancer, and for monitoring therapeutic response than the currently used prostate specific antigen (PSA). Prostate specific membrane antigen...
10.
Bumb A, Brechbiel M, Choyke P, Fugger L, Eggeman A, Prabhakaran D, et al.
Nanotechnology
. 2009 Aug;
19(33):335601.
PMID: 19701448
Ultra-small superparamagnetic iron oxide nanoparticles (SPIOs) were synthesized by co-precipitation of iron chloride salts with ammonia and then encapsulated with thin (~2nm) layers of silica. The particles have been characterized...