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M van Bilsen

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Articles 62
Citations 1157
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Recent Articles
1.
Rech M, Luiken J, Glatz J, van Bilsen M, Schroen B, Nabben M
Sci Rep . 2018 Jan; 8(1):1505. PMID: 29367630
The healthy adult heart primarily relies on fatty acid oxidation (FAO) for energy production but instantaneously adapts its substrate preference in response to physiological or pathological challenges. Accurate FAO measurements...
2.
van Bilsen M, Planavila A
Acta Physiol (Oxf) . 2014 Apr; 211(3):476-90. PMID: 24773697
From the viewpoint of the prevention of cardiovascular disease (CVD) burden, there has been a continuous interest in the detrimental effects of the Western-type high-fat diet for more than half...
3.
Planavila A, Redondo I, Hondares E, Vinciguerra M, Munts C, Iglesias R, et al.
Nat Commun . 2013 Jun; 4:2019. PMID: 23771152
Fibroblast growth factor 21 is an endocrine factor, secreted mainly by the liver, that exerts metabolic actions that favour glucose metabolism. Its role in the heart is unknown. Here we...
4.
Daniels A, van Bilsen M, Janssen B, Brouns A, Cleutjens J, Roemen T, et al.
Acta Physiol (Oxf) . 2010 Feb; 200(1):11-22. PMID: 20175764
Aim: To identify the initial alterations in myocardial tissue associated with the early signs of diabetic cardiac haemodynamic dysfunction, we monitored changes in cardiac function, structural remodelling and gene expression...
5.
Daniels A, van Bilsen M, Goldschmeding R, Van der Vusse G, Van Nieuwenhoven F
Acta Physiol (Oxf) . 2008 Dec; 195(3):321-38. PMID: 19040711
Cardiac fibrosis is a major pathogenic factor in a variety of cardiovascular diseases and refers to an excessive deposition of extracellular matrix components in the heart, which leads to cardiac...
6.
Smeets P, Planavila A, Van der Vusse G, van Bilsen M
Acta Physiol (Oxf) . 2007 Oct; 191(3):171-88. PMID: 17935522
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors acting as key regulators of lipid metabolism as well as modulators of inflammation. The role of PPARalpha and PPARgamma in cardiac ischaemia-reperfusion...
7.
de Brouwer K, Degens H, Aartsen W, Lindhout M, Bitsch N, Gilde A, et al.
J Mol Cell Cardiol . 2006 May; 40(6):838-45. PMID: 16697005
Preferential and specific down-regulation of genes involved in fatty acid (FA) uptake and metabolism is considered a hallmark of severe hypertrophic remodeling and progression to cardiac failure. Therefore, we investigated...
8.
Gilde A, van Bilsen M
Acta Physiol Scand . 2003 Jul; 178(4):425-34. PMID: 12864748
The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. The three isoforms (PPARalpha, beta/delta and gamma) have been implicated in the regulation of the expression of...
9.
Degens H, Gilde A, Lindhout M, Willemsen P, Van der Vusse G, van Bilsen M
Am J Physiol Heart Circ Physiol . 2002 Oct; 284(1):H108-15. PMID: 12388319
In heart failure, thyroid hormone (TH) treatment improves cardiac performance. The long-term effects of TH on cardiac function and metabolism, however, are incompletely known. To investigate the effects of up...
10.
Rouwet E, Tintu A, Schellings M, van Bilsen M, Lutgens E, Hofstra L, et al.
Circulation . 2002 Jun; 105(23):2791-6. PMID: 12057996
Background: Low birth weight is associated with an increased incidence of cardiovascular diseases, including hypertension, later in life. This suggests that antenatal insults program for fetal adaptations of the circulatory...