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M VALIUS

Explore the profile of M VALIUS including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 486
Followers 0
Related Specialties
Cell Biology
Biochemistry
Oncology
Top 10 Co-Authors
A Kazlauskas
J R Vandenheede
W MERLEVEDE
T Vantus
L E Heasley
A Stetak
S Ohtsuka
G Bokonyi
N Ellmore
R R Vaillancourt
Published In
Mol Cell Biol
Oncogene
J Biol Chem
Cell Signal
Cell
Affiliations
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Recent Articles
1.
The somatostatin analogue TT-232 induces apoptosis in A431 cells: sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases
Vantus T, Keri G, Krivickiene Z, VALIUS M, Stetak A, Keppens S, et al.
Cell Signal . 2001 Oct; 13(10):717-25. PMID: 11602182
TT-232 is a somatostatin analogue containing a five-residue ring structure. The present report describes TT-232-induced signalling events in A431 cells, where a 4-h preincubation with the peptide irreversibly induced a...
2.
JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-gamma and the phosphatidylinositol 3-kinase signaling pathways of the receptor
Assefa Z, VALIUS M, Vantus T, Agostinis P, MERLEVEDE W, Vandenheede J
Biochem Biophys Res Commun . 1999 Aug; 261(3):641-5. PMID: 10441479
Wild-type or mutant betaPDGF receptors were introduced into A431 cells that lack endogenous PDGF receptors. PDGF stimulates JNK1 activity in a dose- and time-dependent manner in cells expressing the wild-type...
3.
APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis
Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, et al.
Oncogene . 1999 Feb; 18(3):759-67. PMID: 9989826
Previously we cloned a novel adaptor protein, APS (adaptor molecules containing PH and SH2 domains) which was tyrosine phosphorylated in response to c-kit or B cell receptor stimulation. Here we...
4.
Platelet-derived growth factor stimulates protein kinase D through the activation of phospholipase Cgamma and protein kinase C
Van Lint J, Ni Y, VALIUS M, MERLEVEDE W, Vandenheede J
J Biol Chem . 1998 Apr; 273(12):7038-43. PMID: 9507012
Platelet-derived growth factor (PDGF) stimulates protein kinase D (PKD) in a time- and dose-dependent manner. We have used a series of PDGF receptor mutants that display a selective impairment of...
5.
The platelet-derived growth factor beta receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputs
Montmayeur J, VALIUS M, Vandenheede J, Kazlauskas A
J Biol Chem . 1998 Jan; 272(51):32670-8. PMID: 9405485
Stimulation of the platelet-derived growth factor beta receptor (betaPDGFR) activates enzymes such as phosphatidylinositol 3-kinase (PI3K) and phospholipase Cgamma1 (PLCgamma), which ultimately initiate nuclear responses such as enhanced expression of...
6.
PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells
Alimandi M, Heidaran M, Gutkind J, Zhang J, Ellmore N, VALIUS M, et al.
Oncogene . 1997 Jul; 15(5):585-93. PMID: 9247312
To investigate the molecular mechanisms mediating hematopoietic cell differentiation and mitogenesis by activation of the platelet-derived growth factor beta receptor (PDGF-betaR), the wild type PDGF-betaR (PDGF-betaRWT) and tyrosine to phenylalanine...
7.
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity
Klinghoffer R, Duckworth B, VALIUS M, Cantley L, Kazlauskas A
Mol Cell Biol . 1996 Oct; 16(10):5905-14. PMID: 8816504
Upon binding of platelet-derived growth factor (PDGF), the PDGF beta receptor (PDGFR) undergoes autophosphorylation on distinct tyrosine residues and binds several SH2-domain-containing signal relay enzymes, including phosphatidylinositol 3-kinase (PI3K), phospholipase...
8.
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation
Vaillancourt R, Heasley L, Zamarripa J, Storey B, VALIUS M, Kazlauskas A, et al.
Mol Cell Biol . 1995 Jul; 15(7):3644-53. PMID: 7540718
When expressed in PC12 cells, the platelet-derived growth factor beta receptor (beta PDGF-R) mediates cell differentiation. Mutational analysis of the beta PDGF-R indicated that persistent receptor stimulation of the Ras/Raf/mitogen-activated...
9.
The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1
VALIUS M, Secrist J, Kazlauskas A
Mol Cell Biol . 1995 Jun; 15(6):3058-71. PMID: 7760802
The beta receptor for platelet-derived growth factor (beta PDGFR) is activated by binding of PDGF and undergoes phosphorylation at multiple tyrosine residues. The tyrosine-phosphorylated receptor associates with numerous SH2-domain-containing proteins...
10.
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp
Kazlauskas A, Feng G, Pawson T, VALIUS M
Proc Natl Acad Sci U S A . 1993 Aug; 90(15):6939-43. PMID: 7688466
Ligand-stimulated autophosphorylation of the platelet-derived growth factor receptor (PDGFR) beta subunit creates a number of binding sites for SH2-containing proteins. One of the PDGFR-associated proteins is a 64-kDa protein of...