M Todd Valerius
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Explore the profile of M Todd Valerius including associated specialties, affiliations and a list of published articles.
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45
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Recent Articles
31.
Nagalakshmi V, Ren Q, Pugh M, Valerius M, McMahon A, Yu J
Kidney Int
. 2010 Oct;
79(3):317-30.
PMID: 20944551
MicroRNAs (miRNAs) are a large and growing class of small, non-coding, regulatory RNAs that control gene expression predominantly at the post-transcriptional level. The production of most functional miRNAs depends on...
32.
Humphreys B, Lin S, Kobayashi A, Hudson T, Nowlin B, Bonventre J, et al.
Am J Pathol
. 2009 Dec;
176(1):85-97.
PMID: 20008127
Understanding the origin of myofibroblasts in kidney is of great interest because these cells are responsible for scar formation in fibrotic kidney disease. Recent studies suggest epithelial cells are an...
33.
Georgas K, Rumballe B, Valerius M, Chiu H, Thiagarajan R, Lesieur E, et al.
Dev Biol
. 2009 Jun;
332(2):273-86.
PMID: 19501082
While nephron formation is known to be initiated by a mesenchyme-to-epithelial transition of the cap mesenchyme to form a renal vesicle (RV), the subsequent patterning of the nephron and fusion...
34.
Brunskill E, Aronow B, Georgas K, Rumballe B, Valerius M, Aronow J, et al.
Dev Cell
. 2008 Nov;
15(5):781-91.
PMID: 19000842
Kidney development is based on differential cell-type-specific expression of a vast number of genes. While multiple critical genes and pathways have been elucidated, a genome-wide analysis of gene expression within...
35.
Kobayashi A, Valerius M, Mugford J, Carroll T, Self M, Oliver G, et al.
Cell Stem Cell
. 2008 Aug;
3(2):169-81.
PMID: 18682239
Nephrons, the basic functional units of the kidney, are generated repetitively during kidney organogenesis from a mesenchymal progenitor population. Which cells within this pool give rise to nephrons and how...
36.
Humphreys B, Valerius M, Kobayashi A, Mugford J, Soeung S, Duffield J, et al.
Cell Stem Cell
. 2008 Mar;
2(3):284-91.
PMID: 18371453
Understanding the mechanisms of nephron repair is critical for the design of new therapeutic approaches to treat kidney disease. The kidney can repair after even a severe insult, but whether...
37.
Valerius M, McMahon A
Gene Expr Patterns
. 2008 Mar;
8(5):297-306.
PMID: 18346943
The mature nephron forms from a simple epithelial vesicle into an elaborate structure with distinct regions of specialized physiological function. The molecular components driving the process of nephron development are...
38.
Park J, Valerius M, McMahon A
Development
. 2007 Jun;
134(13):2533-9.
PMID: 17537789
Mammalian nephrons form as a result of a complex morphogenesis and patterning of a simple epithelial precursor, the renal vesicle. Renal vesicles are established from a mesenchymal progenitor population in...
39.
Little M, Brennan J, Georgas K, Davies J, Davidson D, Baldock R, et al.
Gene Expr Patterns
. 2007 Apr;
7(6):680-99.
PMID: 17452023
Cataloguing gene expression during development of the genitourinary tract will increase our understanding not only of this process but also of congenital defects and disease affecting this organ system. We...
40.
Cheng H, Kim M, Valerius M, Surendran K, Schuster-Gossler K, Gossler A, et al.
Development
. 2007 Jan;
134(4):801-11.
PMID: 17229764
The Notch pathway regulates cell fate determination in numerous developmental processes. Here we report that Notch2 acts non-redundantly to control the processes of nephron segmentation through an Rbp-J-dependent process. Notch1...