M Ruth Pazos
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Explore the profile of M Ruth Pazos including associated specialties, affiliations and a list of published articles.
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21
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1022
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Recent Articles
11.
Arruza L, Pazos M, Mohammed N, Escribano N, Lafuente H, Santos M, et al.
Pediatr Res
. 2015 May;
79(3):401-8.
PMID: 25950454
Background: We aimed to investigate whether neonatal hypoxic-ischemic (HI) brain injury induces inflammatory lung damage. Methods: Thus, hypoxic (HYP, FiO2 10% for 30 min), ischemic (ISC, bilateral carotid flow interruption...
12.
Moreno E, Andradas C, Medrano M, Caffarel M, Perez-Gomez E, Blasco-Benito S, et al.
J Biol Chem
. 2014 Jun;
289(32):21960-72.
PMID: 24942731
The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether...
13.
Pazos M, Mohammed N, Lafuente H, Santos M, Martinez-Pinilla E, Moreno E, et al.
Neuropharmacology
. 2013 Apr;
71:282-91.
PMID: 23587650
The mechanisms underlying the neuroprotective effects of cannabidiol (CBD) were studied in vivo using a hypoxic-ischemic (HI) brain injury model in newborn pigs. One- to two-day-old piglets were exposed to...
14.
Fernandez-Ruiz J, Sagredo O, Pazos M, Garcia C, Pertwee R, Mechoulam R, et al.
Br J Clin Pharmacol
. 2012 May;
75(2):323-33.
PMID: 22625422
Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders exerted through molecular mechanisms that are yet to be completely identified. CBD acts in some experimental models as an...
15.
Sagredo O, Pazos M, Valdeolivas S, Fernandez-Ruiz J
Recent Pat CNS Drug Discov
. 2012 Jan;
7(1):41-8.
PMID: 22280340
Cannabinoid pharmacology has experienced a notable increase in the last 3 decades which is allowing the development of novel cannabinoid-based medicines for the treatment of different human pathologies, for example,...
16.
Sagredo O, Pazos M, Satta V, Ramos J, Pertwee R, Fernandez-Ruiz J
J Neurosci Res
. 2011 Jun;
89(9):1509-18.
PMID: 21674569
We studied whether combinations of botanical extracts enriched in either Δ(9)-tetrahydrocannabinol (Δ(9)-THC) or cannabidiol (CBD), which are the main constituents of the cannabis-based medicine Sativex, provide neuroprotection in rat models...
17.
Lafuente H, Alvarez F, Pazos M, Alvarez A, Rey-Santano M, Mielgo V, et al.
Pediatr Res
. 2011 Jun;
70(3):272-7.
PMID: 21654550
Newborn piglets exposed to acute hypoxia-ischemia (HI) received i.v. cannabidiol (HI + CBD) or vehicle (HI + VEH). In HI + VEH, 72 h post-HI brain activity as assessed by...
18.
Blazquez C, Chiarlone A, Sagredo O, Aguado T, Pazos M, Resel E, et al.
Brain
. 2010 Oct;
134(Pt 1):119-36.
PMID: 20929960
Endocannabinoids act as neuromodulatory and neuroprotective cues by engaging type 1 cannabinoid receptors. These receptors are highly abundant in the basal ganglia and play a pivotal role in the control...
19.
Palazuelos J, Aguado T, Pazos M, Julien B, Carrasco C, Resel E, et al.
Brain
. 2009 Oct;
132(Pt 11):3152-64.
PMID: 19805493
Cannabinoid-derived drugs are promising agents for the development of novel neuroprotective strategies. Activation of neuronal CB(1) cannabinoid receptors attenuates excitotoxic glutamatergic neurotransmission, triggers prosurvival signalling pathways and palliates motor symptoms...
20.
Fernandez-Lopez D, Pazos M, Tolon R, Moro M, Romero J, Lizasoain I, et al.
Pediatr Res
. 2007 Jul;
62(3):255-60.
PMID: 17622949
Neonatal hypoxic-ischemic encephalopathy (NHIE) is a devastating condition for which effective therapeutic treatments are still unavailable. Cannabinoids emerge as neuroprotective substances in adult animal studies; therefore, we aimed herein to...