M Ruehl
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Explore the profile of M Ruehl including associated specialties, affiliations and a list of published articles.
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11
Citations
401
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Recent Articles
1.
Freise C, Ruehl M, Erben U, Farndale R, Somasundaram R, Heimesaat M
Eur J Microbiol Immunol (Bp)
. 2014 Apr;
2(3):186-91.
PMID: 24688764
Diseases such as liver fibrosis and intestinal inflammation are characterized by accumulated components of the extracellular matrix (ECM). Given that fibrillar collagen structures were shown to serve as storage site...
2.
Eurich D, Boas-Knoop S, Yahyazadeh A, Neuhaus R, Somasundaram R, Ruehl M, et al.
Transpl Infect Dis
. 2012 Jun;
14(5):488-95.
PMID: 22650645
Unlabelled: The development of liver and graft disease is suspected to be affected by genetic diversity. Mannose-binding lectin-2 (MBL-2) is an important immunomodulatory factor that is involved in complement activation....
3.
Jia J, Bauer M, Cho J, Ruehl M, Milani S, Boigk G, et al.
J Hepatol
. 2001 Oct;
35(3):392-8.
PMID: 11592601
Background/aims: Silymarin reduces hepatic collagen accumulation by 35% in rats with secondary biliary cirrhosis. The aim of the present study was to explore its antifibrotic mechanism. Methods: Thirty female adult...
4.
Jia J, Bauer M, Sedlaczek N, Herbst H, Ruehl M, Hahn E, et al.
J Hepatol
. 2001 Oct;
35(3):386-91.
PMID: 11592600
Background/aims: The liver is the major source of collagen XVIII (C18), the precursor of the angiogenesis inhibitor endostatin. In human liver C18 is mainly expressed by hepatocytes. However, its quantitative...
5.
Schuppan D, Ruehl M, Somasundaram R, Hahn E
Semin Liver Dis
. 2001 Oct;
21(3):351-72.
PMID: 11586465
The extracellular matrix (ECM) provides cells with positional information and a mechanical scaffold for adhesion and migration. It consists of collagens, glycoproteins, proteoglycans, glycosaminoglycans and molecules that are bound specifically...
6.
Sedlaczek N, Jia J, Bauer M, Herbst H, Ruehl M, Hahn E, et al.
Am J Pathol
. 2001 Apr;
158(4):1239-44.
PMID: 11290541
Connective tissue growth factor (CTGF) is a downstream mediator of transforming growth factor-beta1 (TGF-beta1) and thus a potential target for antifibrotic treatment strategies. CTGF is up-regulated in disorders such as...
7.
Jia J, Bauer M, Boigk G, Ruehl M, Schuppan D, Wang B
Zhonghua Gan Zang Bing Za Zhi
. 2000 Nov;
8(5):274-5.
PMID: 11058949
Objective: To measure and study quantitatively the collagen XVIII mRNA in normal and fibrotic rat livers. Methods: We used ribonuclease protection assay to investigate the collagen XVIII mRNA expression in...
8.
Somasundaram R, Ruehl M, Tiling N, Ackermann R, Schmid M, Riecken E, et al.
J Biol Chem
. 2000 Sep;
275(49):38170-5.
PMID: 10982811
The binding of certain growth factors and cytokines to components of the extracellular matrix can regulate their local availability and modulate their biological activities. We show that interleukin 2 (IL-2),...
9.
Cho J, Hocher B, Herbst H, Jia J, Ruehl M, Hahn E, et al.
Gastroenterology
. 2000 Jun;
118(6):1169-78.
PMID: 10833492
Background & Aims: Endothelin 1 induces contraction, proliferation, and collagen synthesis of hepatic stellate cells in vitro, which may be mediated via the endothelin A receptor. It is unknown if...
10.
Schuppan D, Schmid M, Somasundaram R, Ackermann R, Ruehl M, Nakamura T, et al.
Gastroenterology
. 1998 Jan;
114(1):139-52.
PMID: 9428228
Background & Aims: Hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, binds to heparan sulfate. Because immunoreactive HGF can be detected in the interstitial extracellular matrix (ECM), where little...