M R Flack
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Explore the profile of M R Flack including associated specialties, affiliations and a list of published articles.
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13
Citations
241
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Recent Articles
1.
Stanberry L, Simon J, JOHNSON C, Robinson P, Morry J, Flack M, et al.
Vaccine
. 2011 Nov;
30(2):307-16.
PMID: 22079079
Background: Improving the systemic and mucosal immune response following intranasal vaccination could enhance disease protection against respiratory pathogens. We assessed the safety and immunogenicity of a novel nanoemulsion mucosal adjuvant...
2.
Boyd R, Zegarac E, Posvar E, Flack M
Contraception
. 2001 Apr;
63(2):71-6.
PMID: 11292470
The pharmacokinetics and androgenic activity of Estrostep, a new oral contraceptive providing low-dose estrogen in a graduated sequence with a constant dose of progestin, were characterized in an open-label, nonrandomized...
3.
Kim T, Anasti J, Flack M, Kimzey L, Defensor R, Nelson L
Obstet Gynecol
. 1997 May;
89(5 Pt 1):777-9.
PMID: 9166320
Objective: To evaluate the usefulness of routine screening for other associated autoimmune endocrine disorders in patients with karyotypically normal spontaneous premature ovarian failure. Methods: One hundred nineteen women with karyotypically...
4.
Anasti J, Flack M, Froehlich J, Nelson L
J Clin Endocrinol Metab
. 1995 Mar;
80(3):824-8.
PMID: 7883837
Anti-FSH receptor antibodies, detected using animal systems, have been reported in a few patients with premature ovarian failure (POF). However, assays based on animal receptors may be inappropriate for detecting...
5.
Anasti J, Flack M, Froehlich J, Nelson L, Nisula B
J Clin Endocrinol Metab
. 1995 Jan;
80(1):276-9.
PMID: 7829625
Some children with juvenile hypothyroidism exhibit unexplained precocious puberty. Interaction of TSH with the human FSH receptor (hFSH-R) is a possible pathophysiological mechanism for this syndrome that has not been...
6.
Valove F, Finch C, Anasti J, Froehlich J, Flack M
Endocrinology
. 1994 Dec;
135(6):2657-61.
PMID: 7988456
Separate sites for glycoprotein hormone receptor binding and signal transduction have yet to be elucidated. In general, certain peptide regions are thought to be critical for receptor binding, whereas the...
7.
Flack M, Bennet A, Froehlich J, Anasti J, Nisula B
J Clin Endocrinol Metab
. 1994 Sep;
79(3):756-60.
PMID: 8077357
FSH has four asparagine-linked oligosaccharides with variable sialic acid contents, so that FSH is not a single molecule, but a heterogeneous group of isoforms. These isoforms differ in their biological...
8.
Flack M, Froehlich J, Bennet A, Anasti J, Nisula B
J Biol Chem
. 1994 May;
269(19):14015-20.
PMID: 8188681
To determine the specific role of each follicle-stimulating hormone (FSH) oligosaccharide, we mutated Asn to Gln at each glycosylation site (alpha Gln52, alpha Gln78, alpha Gln52-78, beta Gln7, beta Gln24,...
9.
Flack M, Pyle R, Mullen N, Lorenzo B, Wu Y, Knazek R, et al.
J Clin Endocrinol Metab
. 1993 Apr;
76(4):1019-24.
PMID: 8473376
Medical treatment of metastatic adrenal cancer is largely unsuccessful and has considerable toxicity. We previously demonstrated the activity of the plant toxin gossypol against human adrenal cancers in nude mice....
10.
Lash R, Desai R, Zimmerman C, Flack M, Yoshida T, Wondisford F, et al.
J Endocrinol Invest
. 1992 Apr;
15(4):255-63.
PMID: 1512415
In recent studies, site-directed mutagenesis has been used to alter the tripeptide glycosylation recognition sequences of glycoprotein hormone subunits, thereby affecting their structure and function. However, it is not known...