M R Brann
Overview
Explore the profile of M R Brann including associated specialties, affiliations and a list of published articles.
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80
Citations
2738
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Recent Articles
1.
Bakker R, Nicholas M, Smith T, Burstein E, Hacksell U, Timmerman H, et al.
J Pharmacol Exp Ther
. 2007 Apr;
322(1):172-9.
PMID: 17403993
The human histamine H(1) receptor (H(1)R) is a prototypical G protein-coupled receptor and an important, well characterized target for the development of antagonists to treat allergic conditions. Many neuropsychiatric drugs...
2.
Burstein E, Ma J, Wong S, Gao Y, Pham E, Knapp A, et al.
J Pharmacol Exp Ther
. 2005 Sep;
315(3):1278-87.
PMID: 16135699
Drugs that antagonize D2-like receptors are effective antipsychotics, but the debilitating movement disorder side effects associated with these drugs cannot be dissociated from dopamine receptor blockade. The "atypical" antipsychotics have...
3.
Weiner D, Meltzer H, Veinbergs I, Donohue E, Spalding T, Smith T, et al.
Psychopharmacology (Berl)
. 2004 Jul;
177(1-2):207-16.
PMID: 15258717
Rationale: Clozapine is a unique antipsychotic, with efficacy against positive symptoms in treatment-resistant schizophrenic patients, and the ability to improve cognition and treat the negative symptoms characteristic of this disease....
4.
Bakker R, Weiner D, ter Laak T, Beuming T, Zuiderveld O, Edelbroek M, et al.
Mol Pharmacol
. 2004 Feb;
65(3):538-49.
PMID: 14978232
The human histamine H1 receptor (H1R) is an important, well characterized target for the development of antagonists to treat allergic conditions. Many neuropsychiatric drugs are known to potently antagonize the...
5.
Lee A, Rana B, Schiffer H, Schork N, Brann M, Insel P, et al.
Genomics
. 2003 Mar;
81(3):245-8.
PMID: 12659808
The G-protein-coupled receptor (GPCR) superfamily is one of the largest classes of proteins in mammalian genomes. GPCRs mediate diverse physiological functions and are the targets of >50% of all clinical...
6.
Wellendorph P, GOODMAN M, Burstein E, Nash N, Brann M, Weiner D
Neuropharmacology
. 2002 Jun;
42(7):929-40.
PMID: 12069903
The pharmacology of histamine H(3) receptors suggests the presence of distinct receptor isoforms or subtypes. We herein describe multiple, functionally distinct, alternatively spliced isoforms of the human H(3) receptor. Combinatorial...
7.
Weiner D, Burstein E, Nash N, Croston G, Currier E, Vanover K, et al.
J Pharmacol Exp Ther
. 2001 Sep;
299(1):268-76.
PMID: 11561089
We have used a cell-based functional assay to define the pharmacological profiles of a wide range of central nervous system active compounds as agonists, competitive antagonists, and inverse agonists at...
8.
Jensen A, Spalding T, Burstein E, Sheppard P, OHara P, Brann M, et al.
J Biol Chem
. 2000 Jun;
275(38):29547-55.
PMID: 10835431
The calcium-sensing receptor (CaR) belongs to family C of the G-protein-coupled receptor superfamily. To date 14 activating mutations in CaR showing increased sensitivity to Ca(2+) have been identified in humans...
9.
Burstein E, Hesterberg D, Gutkind J, Brann M, Currier E, Messier T
Oncogene
. 1998 Oct;
17(12):1617-23.
PMID: 9794239
Ras and rac are each members of the superfamily of monomeric GTPases and both function as molecular switches to link cell-surface signals to intracellular responses. Using a novel assay of...
10.
Burstein E, Spalding T, Brann M
J Biol Chem
. 1998 Sep;
273(38):24322-7.
PMID: 9733718
We have completed a systematic search of the intracellular loops of a muscarinic acetylcholine receptor for domains that govern G-protein coupling. A unique feature of the second intracellular (i2) loop...