M P Rathbone
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Explore the profile of M P Rathbone including associated specialties, affiliations and a list of published articles.
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72
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1069
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Recent Articles
11.
Glasky A, Glasky M, Ritzmann R, Rathbone M
Expert Opin Investig Drugs
. 2005 Jul;
6(10):1413-7.
PMID: 15989510
Preclinical and clinical evidence support the effectiveness of neurotrophins in Alzheimer's disease (AD) and neurodegenerative diseases. Delivery of neurotrophins to target sites in the brain remains a major obstacle for...
12.
Guarnieri S, Fano G, Rathbone M, Mariggio M
Neuroscience
. 2004 Oct;
128(4):697-712.
PMID: 15464278
Guanosine 5' triphosphate (GTP), acting synergistically with the nerve growth factor (NGF), enhances the proportion of neurite-bearing cells in cultures of PC12 rat pheochromocytoma cells. We studied the transduction mechanisms...
13.
Jiang S, Khan M, Middlemiss P, Lu Y, Werstiuk E, Crocker C, et al.
Int J Immunopathol Pharmacol
. 2004 Oct;
17(3):353-66.
PMID: 15461869
Extracellular non-adenine based purines are neuroprotective. Preliminary studies indicate that administration of the synthetic purine 4-[[3-(1,6 dihydro-6-oxo-9-purine-9-yl)-1-oxypropyl] amino] benzoic acid (AIT-082, leteprinim potassium) to rats immediately after acute spinal cord...
14.
Chen Y, Rathbone M, Hertz L
J Neurosci Res
. 2001 Jul;
65(2):184-9.
PMID: 11438987
Purinergic receptors play an important role in the regulation of free cytosolic calcium concentration ([Ca(2+)](i)) in astrocytes. In the present study, 10 microM adenosine caused an increase in [Ca(2+)](i) in...
15.
Ciccarelli R, Ballerini P, Sabatino G, Rathbone M, DOnofrio M, Caciagli F, et al.
Int J Dev Neurosci
. 2001 May;
19(4):395-414.
PMID: 11378300
Astrocytes are involved in multiple brain functions in physiological conditions, participating in neuronal development, synaptic activity and homeostatic control of the extracellular environment. They also actively participate in the processes...
16.
Di Iorio P, Virgilio A, Giuliani P, Ballerini P, Vianale G, Middlemiss P, et al.
Exp Neurol
. 2001 May;
169(2):392-9.
PMID: 11358452
4-[[3-(1,6-dihydro-6-oxo-9-purin-9-yl)-1-oxopropyl]amino]benzoic acid (AIT-082) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes. These effects may predict an in vivo neuroprotective...
17.
Rathbone M, Middlemiss P, Gysbers J, Andrew C, Herman M, Reed J, et al.
Prog Neurobiol
. 2000 Jun;
59(6):663-90.
PMID: 10845757
In addition to their well known roles within cells, purine nucleotides such as adenosine 5' triphosphate (ATP) and guanosine 5' triphosphate (GTP), nucleosides such as adenosine and guanosine and bases,...
18.
Gysbers J, Guarnieri S, Mariggio M, Pietrangelo T, Fano G, Rathbone M
Neuroscience
. 2000 Mar;
96(4):817-24.
PMID: 10727799
Extracellular guanosine 5' triphosphate (GTP) enhances nerve growth factor-dependent neurite outgrowth from rat pheochromocytoma (PC12) cells; cultures of PC12 cells exposed to GTP and nerve growth factor together contain significantly...
19.
Ciccarelli R, Di Iorio P, DAlimonte I, Giuliani P, Florio T, Caciagli F, et al.
Glia
. 2000 Jan;
29(3):202-11.
PMID: 10642747
Extracellular adenosine (Ado) and ATP stimulate astrocyte proliferation through activation of P(1) and P(2) purinoceptors. Extracellular GTP and guanosine (Guo), however, that do not bind strongly to these receptors, are...
20.
Ciccarelli R, Di Iorio P, Giuliani P, DAlimonte I, Ballerini P, Caciagli F, et al.
Glia
. 1999 Jan;
25(1):93-8.
PMID: 9888301
Brain ischemia stimulates release from astrocytes of adenine-based purines, particularly adenosine, which is neuroprotective. Guanosine, which has trophic properties that may aid recovery following neurological damage, is present in high...