M P McKinley
Overview
Explore the profile of M P McKinley including associated specialties, affiliations and a list of published articles.
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48
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Recent Articles
1.
Holtzman D, Li Y, DeArmond S, McKinley M, Gage F, Epstein C, et al.
Proc Natl Acad Sci U S A
. 1992 Feb;
89(4):1383-7.
PMID: 1741393
Vulnerability of specific brain regions and neuronal populations is a characteristic feature of Alzheimer disease and Down syndrome. Cholinergic neurons of the basal forebrain degenerate in both disorders. The basis...
2.
McKinley M, Taraboulos A, Kenaga L, Serban D, Stieber A, DeArmond S, et al.
Lab Invest
. 1991 Dec;
65(6):622-30.
PMID: 1684401
Infectious scrapie prions are composed largely, if not entirely, of an abnormal isoform of the prion protein (PrP) designated PrPSc. In scrapie-infected mouse neuroblastoma (ScN2a) and hamster brain (ScHaB) cells,...
3.
McKinley M, MEYER R, Kenaga L, Rahbar F, Cotter R, Serban A, et al.
J Virol
. 1991 Mar;
65(3):1340-51.
PMID: 1704926
Scrapie prion infectivity can be enriched from hamster brain homogenates by using limited proteolysis and detergent extraction. Purified fractions contain both scrapie infectivity and the protein PrP 27-30, which is...
4.
Holtzman D, Li Y, Gage F, DeArmond S, Epstein C, McKinley M, et al.
Prog Clin Biol Res
. 1991 Jan;
373:189-202.
PMID: 1838184
No abstract available.
5.
McKinley M, Prusiner S
Curr Top Microbiol Immunol
. 1991 Jan;
172:75-91.
PMID: 1725771
No abstract available.
6.
Taraboulos A, Rogers M, Borchelt D, McKinley M, Scott M, Serban D, et al.
Proc Natl Acad Sci U S A
. 1990 Nov;
87(21):8262-6.
PMID: 1978322
The scrapie and cellular isoforms of the prion protein (PrPSc and PrPC) differ strikingly in a number of their biochemical and metabolic properties. The structural features underlying these differences are...
7.
Lowenstein D, Butler D, Westaway D, McKinley M, DeArmond S, Prusiner S
Mol Cell Biol
. 1990 Mar;
10(3):1153-63.
PMID: 2406562
Given the critical role of the prion protein (PrP) in the transmission and pathogenesis of experimental scrapie, we investigated the PrP gene and its protein products in three hamster species,...
8.
McKinley M, Longo F, Valletta J, Rahbar F, Neve R, Prusiner S, et al.
Prog Brain Res
. 1990 Jan;
86:227-38.
PMID: 1982367
No abstract available.
9.
McKinley M, DeArmond S, Torchia M, Mobley W, Prusiner S
Neurology
. 1989 Oct;
39(10):1319-24.
PMID: 2507957
Prions cause Creutzfeldt-Jakob disease, Gerstmann-Sträussler syndrome, and kuru of humans as well as scrapie of animals. Prolonged incubation periods, from months to decades, precede clinical disease. In studies on the...
10.
Gabizon R, McKinley M, Groth D, Westaway D, DeArmond S, Carlson G, et al.
Prog Clin Biol Res
. 1989 Jan;
317:583-600.
PMID: 2574871
The scrapie agent causes a degenerative neurologic disease and can be transmitted to laboratory rodents. The unusual properties of the scrapie agent prompted introduction of the term prion in order...