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M Morillas

Explore the profile of M Morillas including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 506
Followers 0
Related Specialties
Biochemistry
Cardiology & Vascular Diseases
Microbiology
Top 10 Co-Authors
W Swietnicki
W K Surewicz
N Murga
F G Hegardt
G Asins
D Serra
D Sagastagoitia
M Iriarte
A Salcedo
P Gambetti
Published In
J Biol Chem
Rev Esp Cardiol
Biochemistry
Eur Heart J
Biochem J
Affiliations
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Recent Articles
1.
Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity
Morillas M, Gomez-Puertas P, Roca R, Serra D, Asins G, Valencia A, et al.
J Biol Chem . 2001 Sep; 276(48):45001-8. PMID: 11553629
Carnitine palmitoyltransferase I (CPT I) and carnitine octanoyltransferase (COT) catalyze the conversion of long- and medium-chain acyl-CoA to acylcarnitines in the presence of carnitine. We propose a common three-dimensional structural...
2.
Crystal structure of the human prion protein reveals a mechanism for oligomerization
Knaus K, Morillas M, Swietnicki W, Malone M, Surewicz W, Yee V
Nat Struct Biol . 2001 Aug; 8(9):770-4. PMID: 11524679
The pathogenesis of transmissible encephalopathies is associated with the conversion of the cellular prion protein, PrP(C), into a conformationally altered oligomeric form, PrP(Sc). Here we report the crystal structure of...
3.
On the mechanism of alpha-helix to beta-sheet transition in the recombinant prion protein
Morillas M, Vanik D, Surewicz W
Biochemistry . 2001 Jun; 40(23):6982-7. PMID: 11389614
It is believed that the critical event in the pathogenesis of transmissible spongiform encephalopathies is the conversion of the prion protein from an alpha-helical form, PrP(C), to a beta-sheet-rich conformer,...
4.
Post-transcriptional regulation of rat carnitine octanoyltransferase
Hegardt F, Bach M, Asins G, Caudevilla C, Morillas M, Codony C, et al.
Biochem Soc Trans . 2001 May; 29(Pt 2):316-20. PMID: 11356174
Carnitine octanoyltransferase (COT) produces three different transcripts in rat through cis- and trans-splicing reactions, which can lead to the synthesis of two proteins. The occurrence of the three COT transcripts...
5.
The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein
Gabus C, Auxilien S, Pechoux C, Dormont D, Swietnicki W, Morillas M, et al.
J Mol Biol . 2001 Apr; 307(4):1011-21. PMID: 11286552
The transmissible spongiform encephalopathies are fatal neurodegenerative diseases that are associated with the accumulation of a protease-resistant form of the cellular prion protein (PrP). Although PrP is highly conserved and...
6.
The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1
Gabus C, Derrington E, Leblanc P, Chnaiderman J, Dormont D, Swietnicki W, et al.
J Biol Chem . 2001 Mar; 276(22):19301-9. PMID: 11278562
Transmissible spongiform encephalopathies are fatal neurodegenerative diseases associated with the accumulation of a protease-resistant form of the prion protein (PrP). Although PrP is conserved in vertebrates, its function remains to...
7.
Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues
Morillas M, Clotet J, Rubi B, Serra D, Arino J, Hegardt F, et al.
Biochem J . 2000 Oct; 351 Pt 2:495-502. PMID: 11023836
Rat peroxisomal carnitine octanoyltransferase (COT), which facilitates the transport of medium-chain fatty acids through the peroxisomal membrane, is irreversibly inhibited by the hypoglycaemia-inducing drug etomoxir. To identify the molecular basis...
8.
Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus
Li R, Liu T, Wong B, Pan T, Morillas M, Swietnicki W, et al.
J Mol Biol . 2000 Sep; 301(3):567-73. PMID: 10966770
We have characterized the epitopes of a panel of 12 monoclonal antibodies (Mabs) directed to normal human cellular prion protein (PrP(C)) using ELISA and Western blotting of recombinant PrP or...
9.
Identification of the two histidine residues responsible for the inhibition by malonyl-CoA in peroxisomal carnitine octanoyltransferase from rat liver
Morillas M, Clotet J, Rubi B, Serra D, Asins G, Arino J, et al.
FEBS Lett . 2000 Jan; 466(1):183-6. PMID: 10648838
Carnitine octanoyltransferase (COT), an enzyme that facilitates the transport of medium chain fatty acids through peroxisomal membranes, is inhibited by malonyl-CoA. cDNAs encoding full-length wild-type COT and one double mutant...
10.
Aggregation and fibrillization of the recombinant human prion protein huPrP90-231
Swietnicki W, Morillas M, Chen S, Gambetti P, Surewicz W
Biochemistry . 2000 Jan; 39(2):424-31. PMID: 10631004
According to the "protein-only" hypothesis, the critical step in the pathogenesis of prion diseases is the conformational transition between the normal (PrP(C)) and pathological (PrP(Sc)) isoforms of prion protein. To...