M Laird Forrest
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Explore the profile of M Laird Forrest including associated specialties, affiliations and a list of published articles.
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98
Citations
2117
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Recent Articles
11.
Pressnall M, Huang A, Groer C, Huayamares S, Forrest M, Berkland C
Int J Pharm
. 2021 Jun;
605:120812.
PMID: 34144136
Cancer immunotherapy aims to stimulate immune cells to recognize and attack tumor tissue. The immunostimulatory polyanions polyI:C and CpG induce potent pro-inflammatory immune responses as TLR3 and TLR9 agonists, respectively....
12.
Ultrasound-assisted laser thrombolysis with endovascular laser and high-intensity focused ultrasound
Jo J, Forrest M, Yang X
Med Phys
. 2020 Dec;
48(2):579-586.
PMID: 33280145
Purpose: The combination of laser and ultrasound can significantly improve the efficiency of thrombolysis through an enhanced cavitation effect. We developed a fiber optics-based laser-ultrasound thrombolysis device and tested the...
13.
Huayamares S, Song J, Huang A, Crowl S, Groer C, Forrest M, et al.
Macromol Biosci
. 2020 Sep;
20(12):e2000251.
PMID: 32924274
Designing an in vitro model of the tumor extracellular microenvironment to screen intratumoral drugs is an active challenge. As recent clinical successes of human intratumoral therapies stimulate research on intratumoral...
14.
Huang A, Pressnall M, Lu R, Huayamares S, Griffin J, Groer C, et al.
J Control Release
. 2020 Jul;
326:203-221.
PMID: 32673633
Cancer therapies aim to kill tumor cells directly or engage the immune system to fight malignancy. Checkpoint inhibitors, oncolytic viruses, cell-based immunotherapies, cytokines, and adjuvants have been applied to prompt...
15.
Hunt J, Kleindl P, Moulder K, Prisinzano T, Forrest M
Bioorg Med Chem Lett
. 2019 Dec;
30(2):126788.
PMID: 31784317
Small molecule agonists of TLR7/8, such as imidazoquinolines, are validated agonists for the treatment of cancer and for use in vaccine adjuvants. Imidazoquinolines have been extensively modified to understand the...
16.
Varkhede N, Bommana R, Schoneich C, Forrest M
J Pharm Sci
. 2019 Aug;
109(1):191-205.
PMID: 31408633
The intradermal (ID) and subcutaneous (SC) routes are commonly used for therapeutic proteins (TPs) and vaccines; however, the bioavailability of TPs is typically less than small molecule drugs given via...
17.
Varkhede N, Peters B, Wei Y, Middaugh C, Schoneich C, Forrest M
J Pharm Sci
. 2019 Jun;
108(10):3372-3381.
PMID: 31216451
Oxidation of therapeutic proteins (TPs) can lead to changes in their pharmacokinetics, biological activity and immunogenicity. Metal impurities such as iron are known to increase oxidation of TPs, but nanoparticulate...
18.
Lu R, Groer C, Kleindl P, Moulder K, Huang A, Hunt J, et al.
J Control Release
. 2019 Jun;
306:165-176.
PMID: 31173789
The toll-like receptor 7 and 8 (TLR7/8) agonist Resiquimod (R848) has been recognized as a promising immunostimulator for the treatment of cutaneous cancers in multiple clinical trials. However, systemic administration...
19.
Mozziconacci O, Stobaugh J, Bommana R, Woods J, Franklin E, Jorgenson J, et al.
Chromatographia
. 2019 Jan;
80(9):1299-1318.
PMID: 30686829
In recent years protein therapeutics have seen increasing use in the therapeutic arena. As with traditional small molecule drug substances, one is obligated to ensure purity and stability of the...
20.
Song J, Larson N, Thati S, Torres-Vazquez I, Martinez-Rivera N, Subelzu N, et al.
J Control Release
. 2018 Nov;
293:36-47.
PMID: 30414463
Glatiramer acetate (GA) is widely prescribed for the treatment of relapsing-remitting multiple sclerosis, however, the mechanism of action is still not fully understood. We investigated the structural properties of GA...