M L Michaelis
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Explore the profile of M L Michaelis including associated specialties, affiliations and a list of published articles.
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55
Citations
463
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Recent Articles
1.
Seyb K, Schuman E, Ni J, Huang M, Michaelis M, Glicksman M
J Biomol Screen
. 2008 Sep;
13(9):870-8.
PMID: 18812568
Calpain activation is hypothesized to be an early occurrence in the sequence of events resulting in neurodegeneration, as well as in the signaling pathways linking extracellular accumulation of beta-amyloid (Abeta)...
2.
Michaelis M, Seyb K, Ansar S
Curr Alzheimer Res
. 2005 Jun;
2(2):227-9.
PMID: 15974922
The cytoskeleton provides structural integrity and determines localization of proteins and organelles throughout the cell. The focus on structure and transport has overshadowed the role this ubiquitous network plays in...
3.
Michaelis M, Ansar S, Chen Y, Reiff E, Seyb K, Himes R, et al.
J Pharmacol Exp Ther
. 2004 Sep;
312(2):659-68.
PMID: 15375176
Deposition of beta-amyloid peptide (Abeta) and hyperphosphorylation of the tau protein are associated with neuronal dysfunction and cell death in Alzheimer's disease. Although the relationship between these two processes is...
4.
Bland K, Huschenbett J, Ramonda L, Bechtel M, Zaidi A, Michaelis M
Neurosci Lett
. 2000 Oct;
294(1):13-6.
PMID: 11044575
An antisense (AS) oligodeoxynucleotide based on a conserved sequence in the three isoforms of the Na(+)/Ca(2+) exchanger (NCX) was used to decrease expression of this Ca(2+) transporter in primary neuronal...
5.
Zaidi A, Michaelis M
Free Radic Biol Med
. 1999 Oct;
27(7-8):810-21.
PMID: 10515585
The regulation of free intracellular calcium [Ca2+]i is altered in neurons from the aged brain, possibly due to reductions in the activity of Ca2+ transporters. The plasma membrane Ca(2+)-ATPase (PMCA)...
6.
Takahashi K, Azuma M, Huschenbett J, Michaelis M, Azuma J
Biochem Biophys Res Commun
. 1999 Jun;
260(1):117-21.
PMID: 10381353
The present study was designed to explore the role of the Na+/Ca2+ exchanger on spontaneous beating of cultured cardiac myocytes. Antisense oligonucleotides (AS) based on the sequence of the cardiac...
7.
Zaidi A, Gao J, Squier T, Michaelis M
Neurobiol Aging
. 1999 Jan;
19(5):487-95.
PMID: 9880051
We used Fisher 344/Brown Norway hybrid rats (F344/BNF1) to determine whether previously reported decreases in brain synaptic plasma membrane (SPM) Ca2+-ATPase activity in inbred F344 rats also occurred in the...
8.
Qin Z, Zaidi A, Gao J, Krainev A, Michaelis M, Squier T, et al.
Mech Ageing Dev
. 1998 Dec;
105(3):291-300.
PMID: 9862236
We have examined lipid peroxidation (LPO) and fatty acid acyl chain dynamics in synaptosomal membranes isolated from aged rat (Fischer 344 x Brown Norway F1 hybrids) brains, correlating these results...
9.
Huschenbett J, Zaidi A, Michaelis M
Biochim Biophys Acta
. 1998 Nov;
1374(1-2):34-46.
PMID: 9814850
Two plasma membrane proteins, the Na+/Ca2+ exchanger (NCX) and the Ca2+-ATPase, are major regulators of free intraneuronal Ca2+ levels as they are responsible for extrusion of Ca2+ from the intracellular...
10.
Michaelis M, Ranciat N, Chen Y, Bechtel M, Ragan R, Hepperle M, et al.
J Neurochem
. 1998 Apr;
70(4):1623-7.
PMID: 9523579
Neurofibrillary tangles in Alzheimer's disease contain aggregates of abnormally phosphorylated microtubule-associated protein tau, indicating that microtubule breakdown is a primary event in the neurodegenerative cascade. Recent studies have shown that...