M L McCaleb
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Explore the profile of M L McCaleb including associated specialties, affiliations and a list of published articles.
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32
Citations
290
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Recent Articles
1.
Bannon A, Seda J, Carmouche M, Francis J, Norman M, Karbon B, et al.
Brain Res
. 2000 Jun;
868(1):79-87.
PMID: 10841890
An extensive behavioral characterization was conducted with mice lacking the gene for neuropeptide Y (NPY) including response to 24 and 48 h fast and challenge with small molecule antagonists of...
2.
Gregor P, Feng Y, DeCarr L, Cornfield L, McCaleb M
J Biol Chem
. 1996 Nov;
271(44):27776-81.
PMID: 8910373
The family of mammalian neuropeptide Y (NPY)/peptide YY (PYY)/pancreatic polypeptide (PP) receptors comprises several G protein-coupled receptors, i.e. Y1, Y2, and Y4/PP1. We now report cloning of a novel member...
3.
Hu Y, Bloomquist B, Cornfield L, DeCarr L, Friedman L, Jiang P, et al.
J Biol Chem
. 1996 Oct;
271(42):26315-9.
PMID: 8824284
Neuropeptide Y (NPY) plays important roles in the central control of appetite and energy balance, but the receptor subtype responsible for this function has not been cloned. Here we report...
4.
Kees K, Fitzgerald Jr J, Steiner K, Mattes J, Mihan B, Tosi T, et al.
J Med Chem
. 1996 Sep;
39(20):3920-8.
PMID: 8831758
The synthesis, structure-activity relationship (SAR) studies, and antidiabetic characterization of 1,2-dihydro-4-[[4-(methylthio)phenyl]methyl]-5-(trifluoromethyl)-3H- pyrazol-3-one (as the hydroxy tautomer; WAY-123783, 4) are described. Substitution of 4-methylthio, methylsulfinyl, or ethyl to a benzyl group...
5.
Gregor P, Millham M, Feng Y, DeCarr L, McCaleb M, Cornfield L
FEBS Lett
. 1996 Feb;
381(1-2):58-62.
PMID: 8641440
We report isolation of a murine gene, NPYR-D, which predicts an intronless novel G protein-coupled receptor of 375 amino acids. Percent identities of NPYR-D to the clone Y1, Y2, rat...
6.
Kees K, Caggiano T, Steiner K, Fitzgerald Jr J, Kates M, Christos T, et al.
J Med Chem
. 1995 Feb;
38(4):617-28.
PMID: 7861410
Bioisosteric substitution was used as a tool to generate several new structural alternatives to the thiazolidine-2,4-dione and tetrazole heterocycles as potential antidiabetic agents. Among the initial leads that emerged from...
7.
McCaleb M, Sredy J
Metabolism
. 1992 May;
41(5):522-5.
PMID: 1588832
In a cross-sectional study, we evaluated the metabolic profiles of lean (Fa/?) and obese (fa/fa) Zucker male rats at 4 to 8 months of age. Although all of the obese...
8.
Ellinboe J, Alessi T, Dolak T, Nguyen T, Tomer J, Guzzo F, et al.
J Med Chem
. 1992 Apr;
35(7):1176-83.
PMID: 1560432
A series of substituted 3H-1,2,3,5-oxathiadiazole-2-oxides (6) was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus. The oxathiadiazoles 6 were...
9.
Kees K, Smith T, McCaleb M, Prozialeck D, Cheeseman R, Christos T, et al.
J Med Chem
. 1992 Mar;
35(5):944-53.
PMID: 1548684
In a preliminary communication (J. Med. Chem. 1989, 32, 11-13) a series of perfluoro-N-[4-(1H-tetrazol-5ylmethyl)phenyl]alkana mides (perfluoro anilides I), designed as novel analogues of ciglitazone, were reported to possess oral antidiabetic...
10.
McCaleb M, McKean M, Hohman T, Laver N, Robison Jr W
Diabetologia
. 1991 Oct;
34(10):695-701.
PMID: 1959701
The progressive increase in urinary albumin excretion, which precedes the development of diabetic nephropathy, can be prevented in diabetic rats if the aldose reductase inhibitor, tolrestat, is administered at the...