M L Hermiston
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Explore the profile of M L Hermiston including associated specialties, affiliations and a list of published articles.
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11
Citations
897
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Recent Articles
1.
Delgado-Martin C, Meyer L, Huang B, Shimano K, Zinter M, Nguyen J, et al.
Leukemia
. 2017 May;
31(12):2568-2576.
PMID: 28484265
While outcomes for children with T-cell acute lymphoblastic leukemia (T-ALL) have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid (GC) resistance is...
2.
Fazeli A, Dickinson S, Hermiston M, Tighe R, Steen R, Small C, et al.
Nature
. 1997 Apr;
386(6627):796-804.
PMID: 9126737
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided...
3.
Wong M, Hermiston M, Syder A, Gordon J
Proc Natl Acad Sci U S A
. 1996 Sep;
93(18):9588-93.
PMID: 8790374
Mutations of the human adenomatosis polyposis coli (APC) gene are associated with the development of familial as well as sporadic intestinal neoplasia. To examine the in vivo function of APC,...
4.
Hermiston M, Wong M, Gordon J
Genes Dev
. 1996 Apr;
10(8):985-96.
PMID: 8608945
The adult mouse small intestinal epithelium is self-renewing. Its crypt-villus unit provides a model for studying many of the processes that occur during tissue morphogenesis such as control of proliferative...
5.
Hermiston M, Gordon J
Science
. 1995 Nov;
270(5239):1203-7.
PMID: 7502046
Cadherins mediate cell adhesion and are essential for normal development. Embryonic stem cells were transfected with a dominant negative N-cadherin mutant (NCAD delta) under the control of promoters active in...
6.
Hermiston M, Gordon J
Am J Physiol
. 1995 May;
268(5 Pt 1):G813-22.
PMID: 7762665
The small intestinal crypt of the adult mouse represents a model system for studying cell renewal. One or more functionally equivalent stem cells located within the crypt fuel a continuous...
7.
Hermiston M, Gordon J
J Cell Biol
. 1995 Apr;
129(2):489-506.
PMID: 7721948
A model system is described for defining the physiologic functions of mammalian cadherins in vivo. 129/Sv embryonic stem (ES) cells, stably transfected with a dominant negative N-cadherin mutant (NCAD delta)...
8.
Gordon J, Hermiston M
Curr Opin Cell Biol
. 1994 Dec;
6(6):795-803.
PMID: 7880525
The mouse gut epithelium represents a dynamic, geographically well organized, developmental system for examining self-renewal and differentiation. Reagents are now available for identifying the molecular mechanisms that regulate cell fate...
9.
Hermiston M, Green R, Gordon J
Proc Natl Acad Sci U S A
. 1993 Oct;
90(19):8866-70.
PMID: 8415622
An in vivo system has been developed for examining the effects of wild-type or mutant proteins on cell fate determination in the mouse intestinal epithelium or on the proliferation and...
10.
Hermiston M, Latham C, Gordon J, Roth K
J Histochem Cytochem
. 1992 Sep;
40(9):1283-90.
PMID: 1506665
To study the geographic differentiation of the intestinal epithelium and to understand the complex lineage relationships of its cell populations, it is often necessary to visualize the protein products of...