M Groudine
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Explore the profile of M Groudine including associated specialties, affiliations and a list of published articles.
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Articles
130
Citations
7578
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Recent Articles
1.
Schubeler D, Lorincz M, Groudine M
Sci STKE
. 2001 Dec;
2001(83):pl1.
PMID: 11752652
DNA methylation has emerged as an important component of transcriptional regulation. However, our understanding of how DNA methylation influences transcription, chromatin structure, replication timing, and imprinting has been limited by...
2.
Lorincz M, Schubeler D, Groudine M
Mol Cell Biol
. 2001 Nov;
21(23):7913-22.
PMID: 11689684
The majority of 5-methylcytosine in mammalian DNA resides in endogenous transposable elements and is associated with the transcriptional silencing of these parasitic elements. Methylation also plays an important role in...
3.
Francastel C, Magis W, Groudine M
Proc Natl Acad Sci U S A
. 2001 Oct;
98(21):12120-5.
PMID: 11593025
Murine erythroleukemia (MEL) cells are a model system to study reorganization of the eukaryotic nucleus during terminal differentiation. Upon chemical induction, MEL cells undergo erythroid differentiation, leading to activation of...
4.
Bender M, Roach J, Halow J, Close J, Alami R, Bouhassira E, et al.
Blood
. 2001 Sep;
98(7):2022-7.
PMID: 11567985
The mammalian beta-globin locus is a multigenic, developmentally regulated, tissue-specific locus from which gene expression is regulated by a distal regulatory region, the locus control region (LCR). The functional mechanism...
5.
Schubeler D, Groudine M, Bender M
Proc Natl Acad Sci U S A
. 2001 Sep;
98(20):11432-7.
PMID: 11553791
Locus control regions (LCRs) are defined by their ability to confer high-level tissue-specific expression to linked genes in transgenic assays. Previously, we reported that, at its native site, the murine...
6.
Lorincz M, Groudine M
Proc Natl Acad Sci U S A
. 2001 Aug;
98(18):10034-6.
PMID: 11526227
No abstract available.
7.
Sawado T, Igarashi K, Groudine M
Proc Natl Acad Sci U S A
. 2001 Aug;
98(18):10226-31.
PMID: 11517325
The mouse beta-globin gene locus control region (LCR), located upstream of the beta-globin gene cluster, is essential for the activated transcription of genes in the cluster. The LCR contains multiple...
8.
Tsuji K, KRAUT N, Groudine M, Noda M
Biochim Biophys Acta
. 2001 Jun;
1539(1-2):122-30.
PMID: 11389974
I-mfa (inhibitor of the MyoD family) is a transcription modulator that binds to and suppresses the transcriptional activity of MyoD family members. I-mfa transcripts are expressed in sclerotome, suggesting a...
9.
10.
Francastel C, Schubeler D, Martin D, Groudine M
Nat Rev Mol Cell Biol
. 2001 Mar;
1(2):137-43.
PMID: 11253366
The regulated expression of genes during development and differentiation is influenced by the availability of regulatory proteins and accessibility of the DNA to the transcriptional apparatus. There is growing evidence...