M G Goodman
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Explore the profile of M G Goodman including associated specialties, affiliations and a list of published articles.
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Recent Articles
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Goodman M
Immunol Today
. 2014 Oct;
5(11):319-24.
PMID: 25290756
The C8-substituted guanine ribonucleosides area recently described class of immunomodulator which among a variety of pleiotropic effects have T-cell-replacing activity in vitro and immunopotentiating activity in immunocompromised hosts. In this...
3.
Goodman M
Immunol Today
. 2014 Oct;
1(5):92-6.
PMID: 25290165
The responses of B lymphocytes to exogenous stimulation can be antigen-specific or non-specific. Non-specific stimulation by a single agent activates a multitude of clones of B cells, each secreting antibody...
4.
Goodman M, Spinosa J, Saven A, Piro L, Wormsley S
Leuk Lymphoma
. 1996 Jun;
22(1-2):1-10.
PMID: 8724523
Investigation of the biological actions of loxoribine in chronic lymphocytic leukemia (CLL) was undertaken because of the pervasive immunostimulatory effects of the nucleoside on normal B cells. In vitro studies...
5.
Goodman M, Reitz A, Chen R, Bobardt M, Goodman J, Pope B
J Pharmacol Exp Ther
. 1995 Sep;
274(3):1552-7.
PMID: 7562533
To optimally modulate a system as complex as the immune system, one must ultimately control its elements individually. Up to this time, use of polyclonal immune stimulants has necessarily involved...
6.
Pope B, Macintyre J, Kimball E, Lee S, Zhou L, Taylor G, et al.
Cell Immunol
. 1995 May;
162(2):333-9.
PMID: 7743561
C8- and N7, C8-substituted guanine ribonucleosides comprise a class of molecules with potent immunostimulatory activity for a variety of humoral and cellular immune responses. Although it has been suggested that...
7.
Rivas A, Tintle L, Argentieri D, Kimball E, Goodman M, Anderson D, et al.
Clin Immunol Immunopathol
. 1995 Mar;
74(3):243-51.
PMID: 7859414
A multiple immunodeficiency, involving antibody- and cell-mediated responses in 10 Chinese Shar-Pei (CSP) dogs is described. Abnormal levels of serum IgM and IgA in most cases, and IgG in fewer...
8.
Pope B, Chourmouzis E, Lee S, Goodman M
J Immunother Emphasis Tumor Immunol
. 1995 Feb;
17(2):98-108.
PMID: 7647961
Guanine ribonucleosides with single substitutions at the C8 position (monosubstituted) or with dual substitutions at the C8 and N7 positions (disubstituted) up-regulate a spectrum of immunologic responses, including cytolytic responses...
9.
Goodman M
Pharm Biotechnol
. 1995 Jan;
6:581-609.
PMID: 7551237
Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities. Both loxoribine and its analogues function as agonists of immune responses in a variety of species,...
10.
Pope B, Chourmouzis E, Macintyre J, Lee S, Goodman M
Cell Immunol
. 1994 Dec;
159(2):194-210.
PMID: 7994754
7-Allyl-8-oxoguanosine (loxoribine) is a di-substituted guanine ribonucleoside which has been shown previously to enhance murine NK activity, B lymphocyte proliferation, and antibody synthesis. In this study we examined the relationship...