M F Sheets
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Explore the profile of M F Sheets including associated specialties, affiliations and a list of published articles.
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24
Citations
509
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Recent Articles
1.
Fairey E, Bottein Dechraoui M, Sheets M, Ramsdell J
Biosens Bioelectron
. 2001 Sep;
16(7-8):579-86.
PMID: 11544052
Assays using living cells provide an effective means to generate activity measurements of toxins, especially in situations where the toxins are part of a complex mixture or in an unfamiliar...
2.
Hanck D, Makielski J, Sheets M
Pflugers Arch
. 2000 Apr;
439(6):814-21.
PMID: 10784357
The class IB antiarrhythmic drug, lidocaine, interacts strongly with depolarized sodium (Na) channels, an action that is thought to underlie its clinical efficacy. Previously, we have reported Na channel gating...
3.
Sheets M, KYLE J, Hanck D
J Gen Physiol
. 2000 Apr;
115(5):609-20.
PMID: 10779318
We investigated the contribution of the putative inactivation lid in voltage-gated sodium channels to gating charge immobilization (i.e., the slow return of gating charge during repolarization) by studying a lid-modified...
4.
Sheets M, KYLE J, Kallen R, Hanck D
Biophys J
. 1999 Jul;
77(2):747-57.
PMID: 10423423
Site-3 toxins have been shown to inhibit a component of gating charge (33% of maximum gating charge, Q(max)) in native cardiac Na channels that has been identified with the open-to-inactivated...
5.
Sheets M, Hanck D
J Physiol
. 1998 Dec;
514 ( Pt 2):425-36.
PMID: 9852324
1. Sodium channel ionic current (INa) and gating current (Ig) were compared for rat skeletal (rSkM1) and human heart Na+ channels (hH1a) heterologously expressed in cultured mammalian cells at approximately...
6.
Sheets M, KYLE J, Krueger S, Hanck D
Am J Physiol
. 1996 Sep;
271(3 Pt 1):C1001-6.
PMID: 8843731
We describe a new mammalian expression system that optimizes conditions for the measurement of Na channel gating currents (Ig). The small magnitude of Ig limits their study to preparations with...
7.
Sheets M, Hanck D
J Gen Physiol
. 1995 Oct;
106(4):617-40.
PMID: 8576700
The gating charge and voltage dependence of the open state to the inactivated state (O-->I) transition was measured for the voltage-dependent mammalian cardiac Na channel. Using the site 3 toxin,...
8.
Hanck D, Sheets M
J Gen Physiol
. 1995 Oct;
106(4):601-16.
PMID: 8576699
The site 3 toxin, Anthopleurin-A (Ap-A), was used to modify inactivation of sodium channels in voltage-clamped single canine cardiac Purkinje cells at approximately 12 degrees C. Although Ap-A toxin markedly...
9.
Schackow T, Sheets M, Decker R, Ten Eick R
Am J Physiol
. 1995 Apr;
268(4 Pt 1):C993-1001.
PMID: 7733248
To determine the response of cardiac Na current (INa) in adult cardiac ventricular myocytes to culture, single isolated ventricular myocytes from collagenase-perfused adult cat hearts were placed in primary culture...
10.
Hanck D, Makielski J, Sheets M
J Gen Physiol
. 1994 Jan;
103(1):19-43.
PMID: 8169596
The interaction of antiarrhythmic drugs with ion channels is often described within the context of the modulated receptor hypothesis, which explains the action of drugs by proposing that the binding...