M F Kanz
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Explore the profile of M F Kanz including associated specialties, affiliations and a list of published articles.
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23
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91
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Recent Articles
1.
Dugas T, Santa Cruz V, Liu H, Kanz M
J Toxicol Environ Health A
. 2001 Apr;
62(6):467-83.
PMID: 11289319
Exposure to 4,4'-diaminodiphenylmethane (DAPM) has been linked to jaundice, toxic hepatitis, cholangitis, and cholestasis. In rodents, DAPM initially injures biliary epithelial cells, and toxicity is greater in female than male...
2.
Kanz M, Gunasena G, Kaphalia L, Hammond D, Syed Y
Toxicol Appl Pharmacol
. 1998 Jul;
150(2):414-26.
PMID: 9653073
The threshold for hepatotoxicity and cholestasis induced by methylene dianiline (DAPM) in rats is between 25 and 75 mg/kg (Bailie et al., Environ. Health Perspect., 124, 25-30, 1993). Our objectives...
3.
Gunasena G, Kanz M
J Toxicol Environ Health
. 1997 Oct;
52(2):169-88.
PMID: 9310148
Hyperthyroidism potentiates the in vivo hepatotoxicity of 1,1-dicholoroethylene (DCE) in rats, with a concomitant increase in [14C]-DCE covalent binding. The enhanced injury produced in hyperthyroid livers by DCE could be...
4.
Khan M, Kaphalia B, Prabhakar B, Kanz M, Ansari G
Toxicol Appl Pharmacol
. 1995 Sep;
134(1):155-60.
PMID: 7676450
Trichloroethene (TCE) has been implicated in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE) and scleroderma in humans. However, experimental studies have not been conducted to establish...
5.
Kanz M, Wang A, Campbell G
Toxicol Lett
. 1995 Jul;
78(2):165-71.
PMID: 7618181
Methylene dianiline (4,4'-diaminodiphenylmethane, DAPM) rapidly causes cholestasis and injury to biliary epithelial cells (BEC) in the liver and common bile duct of rats. Our objective was to determine if the...
6.
Moslen M, Kanz M, Bhatia J, Smith C, Rassin D
Exp Mol Pathol
. 1994 Aug;
61(1):1-15.
PMID: 7995375
We studied the effects of a transient elevation in biliary pressure on biliary glutathione and amino acids in rats. Other biliary solutes monitored were total bile salt, Pi, which is...
7.
Kanz M, Kaphalia L, Mohsin S, Taj Z, Moslen M
J Toxicol Environ Health
. 1994 Feb;
41(2):187-206.
PMID: 8301698
Distribution, covalent binding, and biliary excretion of 1,1-dichloroethylene (DCE) were examined in euthyroid (EuT) and hyperthyroid (HyperT) rats, which are more vulnerable to DCE hepatotoxicity. Male Sprague-Dawley rats were made...
8.
Moslen M, Kanz M
Toxicol Appl Pharmacol
. 1993 Sep;
122(1):117-30.
PMID: 8378926
Our objective was to characterize the effects of 1,1-dichloroethylene (DCE, 50 mg/kg) on bile formation by freely moving rats. This toxicant provides a new tool to study structure-function associations because...
9.
Kanz M, Kaphalia L, Kaphalia B, Romagnoli E, Ansari G
Toxicol Appl Pharmacol
. 1992 Nov;
117(1):88-97.
PMID: 1440618
4,4'-Methylene dianiline (4,4'-diaminodiphenylmethane, DAPM), which is used in the polymer industry, causes hepatobiliary damage in exposed humans. Our objectives were to characterize the acute toxicity of DAPM in liver, particularly...
10.
Moslen M, Kanz M, Bhatia J, Kaphalia L, Goldblum R
J Hepatol
. 1992 Sep;
16(1-2):89-97.
PMID: 1484172
Our objective was to determine the effects of hydrostatic biliary pressure on excretion patterns of endogenous solutes which reflect various pathways of bile formation. A stable in vivo model was...