M Eichelbaum
Overview
Explore the profile of M Eichelbaum including associated specialties, affiliations and a list of published articles.
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Articles
264
Citations
5662
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Recent Articles
1.
Saladores P, Murdter T, Eccles D, Chowbay B, Zgheib N, Winter S, et al.
Pharmacogenomics J
. 2014 Aug;
15(1):84-94.
PMID: 25091503
Tamoxifen is the standard-of-care treatment for estrogen receptor-positive premenopausal breast cancer. We examined tamoxifen metabolism via blood metabolite concentrations and germline variations of CYP3A5, CYP2C9, CYP2C19 and CYP2D6 in 587...
2.
Province M, Goetz M, Brauch H, Flockhart D, Hebert J, Whaley R, et al.
Clin Pharmacol Ther
. 2013 Sep;
95(2):216-27.
PMID: 24060820
The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from...
3.
4.
Murdter T, Schroth W, Bacchus-Gerybadze L, Winter S, Heinkele G, Simon W, et al.
Clin Pharmacol Ther
. 2011 Apr;
89(5):708-17.
PMID: 21451508
The therapeutic effect of tamoxifen depends on active metabolites, e.g., cytochrome P450 2D6 (CYP2D6) mediated formation of endoxifen. To test for additional relationships, 236 breast cancer patients were genotyped for...
5.
Tatchev D, Hoell A, Eichelbaum M, Rademann K
Phys Rev Lett
. 2011 Mar;
106(8):085702.
PMID: 21405586
The in situ formation of gold nanoparticles in soda lime silicate glass under constant x-ray irradiation is compared with the ex situ formation in preirradiated glasses. The ASAXS measurements confirm...
6.
Burk O, Brenner S, Hofmann U, Tegude H, Igel S, Schwab M, et al.
Clin Pharmacol Ther
. 2010 Sep;
88(5):685-94.
PMID: 20844484
The impact of thyroid dysfunction on the regulation, expression, and function of ABCB1 remains unclear. We therefore investigated ABCB1 mRNA expression and function in patients with thyroid dysfunction and studied...
7.
Birkenfeld A, Jordan J, Hofmann U, Busjahn A, Franke G, Kruger N, et al.
Clin Pharmacol Ther
. 2009 Sep;
86(6):605-8.
PMID: 19776737
The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe...
8.
Morike K, Kivisto K, Schaeffeler E, Jagle C, Igel S, Drescher S, et al.
Clin Pharmacol Ther
. 2008 Jan;
84(1):104-10.
PMID: 18167502
We studied the efficacy of propafenone in preventing atrial tachyarrhythmias after cardiac surgery, and the possible relationships between CYP2D6 polymorphism and the efficacy, pharmacokinetics, and tolerability of propafenone. One hundred...
9.
Gradhand U, Lang T, Schaeffeler E, Glaeser H, Tegude H, Klein K, et al.
Pharmacogenomics J
. 2007 Apr;
8(1):42-52.
PMID: 17404579
The multidrug resistance protein 4 (MRP4) is an efflux transporter involved in the transport of endogenous substrates and xenobiotics. We measured MRP4 mRNA and protein expression in human livers and...
10.
Saussele T, Burk O, Blievernicht J, Klein K, Nussler A, Nussler N, et al.
Clin Pharmacol Ther
. 2007 Mar;
82(3):265-74.
PMID: 17344806
The pyrazolone drug metamizole is a widely used analgesic. Analysis of liver microsomes from patients treated with metamizole revealed selectively higher expression of cytochromes P450, CYP2B6 and CYP3A4 (3.8- and...