M D Hollenberg
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Explore the profile of M D Hollenberg including associated specialties, affiliations and a list of published articles.
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222
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3545
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Recent Articles
1.
Jenkins D, Jayalath V, Choo V, Viguiliouk E, Kendall C, Srichaikul K, et al.
QJM
. 2020 Jun;
114(6):381-389.
PMID: 32589722
Background: Perhaps, as never before, we need innovators. With our growing population numbers, and with increasing pressures on our education systems, are we in danger of becoming more rigid and...
2.
Polley D, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, et al.
Clin Exp Allergy
. 2017 Mar;
47(7):946-960.
PMID: 28317204
Background: Allergy to the German cockroach (Blattella germanica) is a significant asthma risk factor for inner-city communities. Cockroach, like other allergens, contains trypsin-like enzyme activity that contributes to allergenicity and...
3.
Little P, Hollenberg M, Kamato D, Thomas W, Chen J, Wang T, et al.
Br J Pharmacol
. 2015 Dec;
173(20):2992-3000.
PMID: 26624252
Classically, receptor-mediated signalling was conceived as a linear process involving one agonist, a variety of potential targets within a receptor family (e.g. α- and β-adrenoceptors) and a second messenger (e.g....
4.
Asaduzzaman M, Nadeem A, Arizmendi N, Davidson C, Nichols H, Abel M, et al.
Clin Exp Allergy
. 2015 Aug;
45(12):1844-55.
PMID: 26312432
Background: Proteinase-activated receptor 2 (PAR2 ) is a G protein-coupled receptor activated by trypsin-like serine proteinases. PAR2 activation has been associated with inflammation including allergic airway inflammation. We have also...
5.
Hollenberg M
Br J Pharmacol
. 2014 Dec;
172(13):3196-211.
PMID: 25521749
In keeping with the aim of the Paton Memorial Lecture to 'facilitate the historical study of pharmacology', this overview, which is my distinct honour to write, represents a 'Janus-like' personal...
6.
Alexander S, Benson H, Faccenda E, Pawson A, Sharman J, McGrath J, et al.
Br J Pharmacol
. 2014 Feb;
170(8):1449-58.
PMID: 24528237
The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of...
7.
Hollenberg M, Mihara K, Polley D, Suen J, Han A, Fairlie D, et al.
Br J Pharmacol
. 2013 Dec;
171(5):1180-94.
PMID: 24354792
Although it has been known since the 1960s that trypsin and chymotrypsin can mimic hormone action in tissues, it took until the 1990s to discover that serine proteinases can regulate...
8.
Davidson C, Asaduzzaman M, Arizmendi N, Polley D, Wu Y, Gordon J, et al.
Clin Exp Allergy
. 2013 Oct;
43(11):1274-85.
PMID: 24152160
Background: Many aeroallergens contain proteinase activity and are able to induce allergic sensitization when presented to mucosal surfaces. Some of these allergens activate proteinase-activated receptor-2 (PAR2 ). Objective: To determine...
9.
Russell F, Schuelert N, Veldhoen V, Hollenberg M, McDougall J
Br J Pharmacol
. 2012 Aug;
167(8):1665-78.
PMID: 22849826
Background And Purpose: The PAR(2) receptors are involved in chronic arthritis by mechanisms that are as yet unclear. Here, we examined PAR(2) activation in the rat knee joint. Experimental Approach:...
10.
Li Y, Mihara K, Saifeddine M, Krawetz A, Lau D, Li H, et al.
Br J Pharmacol
. 2011 May;
164(8):1990-2002.
PMID: 21615723
Background And Purpose: We hypothesized that proteinase-activated receptor-2 (PAR2)-mediated vasorelaxation in murine aorta tissue can be due in part to the release of adipocyte-derived relaxing factors (ADRFs). Experimental Approach: Aortic...