M C Tobes
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Explore the profile of M C Tobes including associated specialties, affiliations and a list of published articles.
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23
Citations
440
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Recent Articles
11.
Tobes M, Jaques Jr S, Wieland D, Sisson J
J Nucl Med
. 1985 Aug;
26(8):897-907.
PMID: 3162008
The mechanisms underlying the uptake of the radiopharmaceutical metaiodobenzylguanidine (MIBG) and the catecholamine norepinephrine (NE) were studied using cultured bovine adrenomedullary cells as an in vitro model system. Sodium-dependent and...
12.
Tobes M, Hays S, Gildersleeve D, Wieland D, BEIERWALTES W
J Steroid Biochem
. 1985 Jan;
22(1):103-10.
PMID: 3871878
The adrenal cortical enzyme systems, 11 beta-hydroxylase, P-450 11 beta, and the side-chain cleavage complex, P-450 scc, differ only in their cytochrome P-450s. Structural modifications of metyrapone, an inhibitor of...
13.
Jaques Jr S, Tobes M, Sisson J, Baker J, Wieland D
Mol Pharmacol
. 1984 Nov;
26(3):539-46.
PMID: 6493209
Radioiodinated meta-iodobenzylguanidine (MIBG), a scintigraphic agent used for the detection of human pheochromocytomas, is thought to utilize the same uptake and retention mechanism(s) as norepinephrine (NE). Using cultured bovine adrenomedullary...
14.
Hays S, Tobes M, Gildersleeve D, Wieland D, BEIERWALTES W
J Med Chem
. 1984 Jan;
27(1):15-9.
PMID: 6606707
Metyrapone, 2-methyl-1,2-di-3-pyridyl-1-propanone (1a), is a potent reversible inhibitor of the cytochrome P-450 11 beta-hydroxylase enzyme system (P-450(11) beta) of the adrenal cortex. The structural features of the metyrapone molecule have...
15.
Chin B, Tobes M, Han S
Environ Res
. 1983 Oct;
32(1):167-78.
PMID: 6617609
A system was developed to measure percutaneous absorption of water-insoluble environmental agents into human skin. Percutaneous absorption of 4,4'-[14C]methylenebis [2-chloroaniline] (MBOCA) was measured during dry contact exposure of MBOCA with...
16.
Tobes M, Brown L, Chin B, Marsh D
Toxicol Lett
. 1983 Jun;
17(1-2):69-75.
PMID: 6623511
The tissue distribution kinetics and elimination of 4,4'-methylene bis(2-chloroaniline) (MBOCA) in rats was studied after a single dose of [14C]MBOCA (0.49 mg/kg body weight, i.v.). The highest concentrations of radioactivity...
17.
Sisson J, Frager M, Valk T, Gross M, Swanson D, Wieland D, et al.
N Engl J Med
. 1981 Jul;
305(1):12-7.
PMID: 7231514
We used a new radiopharmaceutical agent, [131I]meta-iodobenzylguanidine ([131I]MIBG), to produce scintigraphic images of pheochromocytomas in eight patients. One day or more after injection, the only normal organ that displayed distinct...
18.
Wieland D, Brown L, Tobes M, Rogers W, Marsh D, Mangner T, et al.
J Nucl Med
. 1981 Apr;
22(4):358-64.
PMID: 7205383
An evaluation of radioiodinated meta-iodobenzylguanidine (m-IBG) as an adrenomedullary imaging agent is reported in 15 rhesus monkeys. Scintiscans of the monkey adrenal medulla have been obtained with [123I]- and [m-131I]IBG...
19.
20.
Tobes M, Mason M
J Biol Chem
. 1977 Jul;
252(13):4591-9.
PMID: 873907
Alpha-Aminoadipate aminotransferase and kynurenine aminotransferase activities were co-purified from the rat kidney supernatant fraction. The resulting preparation was determined to be nearly homogenous by analytical disc gel electrophoresis at pH...