M C Ko
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Explore the profile of M C Ko including associated specialties, affiliations and a list of published articles.
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25
Citations
498
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Recent Articles
1.
Wan K, Liu C, Ko M, Lee W, Huang C
Hong Kong Med J
. 2016 Sep;
22(6):534-7.
PMID: 27609977
Introduction: An elevated serum urate level is recognised as a cause of gouty arthritis and uric acid stone. The level of serum uric acid that accelerates kidney stone formation, however,...
2.
Rizzi A, Sukhtankar D, Ding H, Hayashida K, Ruzza C, Guerrini R, et al.
Br J Pharmacol
. 2015 Apr;
172(14):3661-70.
PMID: 25828800
Background And Purpose: Using an innovative chemical approach, peptide welding technology (PWT), a tetrabranched derivative of nociceptin/orphanin FQ (N/OFQ) has been generated and pharmacologically characterized. Both in vitro and in...
3.
Ding H, Hayashida K, Suto T, Sukhtankar D, Kimura M, Mendenhall V, et al.
Br J Pharmacol
. 2015 Mar;
172(13):3302-12.
PMID: 25752320
Background And Purpose: Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor agonists display a promising analgesic profile in preclinical studies. However, supraspinal N/OFQ produced hyperalgesia in rodents and such effects have not...
4.
Schroder W, Lambert D, Ko M, Koch T
Br J Pharmacol
. 2014 Apr;
171(16):3777-800.
PMID: 24762001
Despite high sequence similarity between NOP (nociceptin/orphanin FQ opioid peptide) and opioid receptors, marked differences in endogenous ligand selectivity, signal transduction, phosphorylation, desensitization, internalization and trafficking have been identified; underscoring...
5.
Molinari S, Camarda V, Rizzi A, Marzola G, Salvadori S, Marzola E, et al.
Br J Pharmacol
. 2012 Jul;
168(1):151-62.
PMID: 22827708
Background And Purpose: Intrathecally (i.t.) administered nociceptin/orphanin FQ (N/OFQ) evokes antinociceptive effects in rodents. Recent studies in monkeys demonstrated that i.t. co-application of N/OFQ and morphine elicits synergistic antinociceptive actions...
6.
Lin C, Lee Y, Liu C, Chen H, Ko M, Li C
Public Health
. 2011 Dec;
126(2):104-11.
PMID: 22178148
Objectives: To depict recent secular trend (2001-2005) in prevalence of depression among diabetic population in Taiwan, and to explore the influences of urbanization on the prevalence of depression. Study Design:...
7.
Zhang H, Ko M
Neuroscience
. 2009 Mar;
161(1):301-10.
PMID: 19303919
Chemical-induced seizures up-regulated brain-derived neurotrophic factor (BDNF) mRNA expression. Intracerebroventricular (i.c.v.) administration of endogenous opioids preferentially activating mu opioid receptor (MOR) could also increase BDNF mRNA expression. The aim of...
8.
Zhang H, Torregrossa M, Jutkiewicz E, Shi Y, Rice K, Woods J, et al.
Eur J Neurosci
. 2006 Mar;
23(4):984-94.
PMID: 16519663
Systemic administration of delta-opioid receptor (DOR) agonists decreases immobility in the forced swim test (FST) and increases brain-derived neurotrophic factor (BDNF) mRNA expression in rats, indicating that DOR agonists may...
9.
Biro T, Ko M, Bromm B, Wei E, Bigliardi P, Siebenhaar F, et al.
Exp Dermatol
. 2005 Mar;
14(3):225-40.
PMID: 15740597
While the enormous clinical and psychosocial importance of pruritus in many areas of medicine and the detrimental effects of chronic 'itch' on the quality of life of an affected individual...
10.
Ko M, Terner J, Hursh S, Woods J, Winger G
J Pharmacol Exp Ther
. 2002 Apr;
301(2):698-704.
PMID: 11961075
The role of duration of action on the relative reinforcing effects of three opioid drugs (fentanyl, alfentanil, and remifentanil) was evaluated. Duration and onset of action were determined using measures...