M C Dyroff
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Explore the profile of M C Dyroff including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
126
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Recent Articles
1.
Gao C, Bui K, Martz A, LeDonne N, Dyroff M
J Chromatogr B Biomed Sci Appl
. 1997 Aug;
695(2):299-307.
PMID: 9300866
A liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS-MS) method is described for the determination of a thromboxane receptor antagonist (4Z)-6-((2S,4S,5R)-2-(1-(2-cyano-4-methylphenoxy)-1-methylethyl)-4 -(3-pyridyl)-3-dioxan-5-yl)hex-4-enoic acid (ZD9583, I) in human plasma and...
2.
Grimm S, Dyroff M
Drug Metab Dispos
. 1997 May;
25(5):598-602.
PMID: 9152599
Anastrozole (2,2'[5(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]- bis(2-methylproprionitrile)) is a potent third-generation inhibitor of aromatase, currently marketed as a treatment for postmenopausal women with advanced breast cancer. While its potency and selectivity for inhibition of...
3.
Grimm S, Dyroff M, Philpot R, Halpert J
Mol Pharmacol
. 1994 Dec;
46(6):1090-9.
PMID: 7808429
Cytochrome P450 (P450) 2B5 was recently found to be functionally distinct from three other rabbit P450 2B forms, based on androstenedione hydroxylase activities. In this investigation, we examined the frequency...
4.
Richardson F, Boucheron J, Dyroff M, Popp J, Swenberg J
Carcinogenesis
. 1986 Feb;
7(2):247-51.
PMID: 2868806
Experiments have demonstrated interlobe differences in the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCCA), with a 100% incidence in the left and right median lobes and a 30% incidence in...
5.
Dyroff M, Richardson F, Popp J, Bedell M, Swenberg J
Carcinogenesis
. 1986 Feb;
7(2):241-6.
PMID: 2868805
Recent experiments have demonstrated that O6-ethyldeoxyguanosine (O6-EtdG) is efficiently repaired while O4-ethyldeoxythymidine (O4-EtdT) accumulates in hepatocyte DNA of 8-week-old F-344 rats during continuous diethylnitrosamine (DEN) administration. To determine if O4-EtdT...
6.
Bedell M, Dyroff M, Doerjer G, Swenberg J
IARC Sci Publ
. 1986 Jan;
(70):425-36.
PMID: 3491789
Etheno adducts can be formed by the reaction of vinyl chloride metabolites with DNA and may play a role in the carcinogenicity of this chemical. These adducts are highly fluorescent...
7.
Swenberg J, Richardson F, Boucheron J, Dyroff M
Environ Health Perspect
. 1985 Oct;
62:177-83.
PMID: 4085420
An impressive array of evidence has been obtained during the past decade establishing correlations between specific DNA adducts and carcinogenesis. Many of the studies utilized organ specific differences in carcinogenesis...
8.
Richardson F, Dyroff M, Boucheron J, Swenberg J
Carcinogenesis
. 1985 Apr;
6(4):625-9.
PMID: 3986964
Recent experiments have demonstrated that O6-alkylguanine is rapidly removed from hepatocyte DNA following continuous exposure to 1,2-dimethylhydrazine or diethylnitrosamine. In contrast, O4-ethyldeoxythymidine accumulates to concentrations more than 50 times greater...
9.
Rickert D, Long R, Dyroff M, Kedderis G
Chem Biol Interact
. 1984 Dec;
52(2):131-9.
PMID: 6595071
The mononitrotoluenes are important industrial chemicals which display isomeric specificity in their ability to induce hepatic DNA excision repair in Fischer-344 rats. Covalent binding of the structurally related hepatocarcinogen, 2,6-dinitrotoluene,...
10.
Kedderis G, Dyroff M, Rickert D
Carcinogenesis
. 1984 Sep;
5(9):1199-204.
PMID: 6590136
The sulfotransferase inhibitors 2,6-dichloro-4-nitrophenol and pentachlorophenol were used to investigate the role of sulfate ester formation during the in vivo bioactivation of 2,4- and 2,6-dinitrotoluene (DNT). Male F-344 rats were...