M C Connelly
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Explore the profile of M C Connelly including associated specialties, affiliations and a list of published articles.
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24
Citations
370
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Recent Articles
1.
NDa D, Lombard M, Clark J, Connelly M, Matheny A, Sigal M, et al.
Drug Res (Stuttg)
. 2013 Feb;
63(2):104-8.
PMID: 23427052
Each year roughly 800 000 people die of malaria, with 95% being African children. The shortcomings of the current drugs and the emergence of P. falciparum resistance to the artemisinin...
2.
Fridland A, Connelly M, Robbins B
Antivir Ther
. 2000 Nov;
5(3):181-5.
PMID: 11075937
Substantial advancements have been made in our understanding of the complex replication cycle of, and immunopathology associated with HIV infection as well as the drugs used to treat the disease....
3.
Schuetz J, Connelly M, Sun D, Paibir S, Flynn P, Srinivas R, et al.
Nat Med
. 1999 Sep;
5(9):1048-51.
PMID: 10470083
Dideoxynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral DNA polymerases, are a common component of highly active anti-retroviral therapy (HAART) (ref. 1). Six reverse transcriptase inhibitors...
4.
Pisarev V, Lee S, Connelly M, Fridland A
Mol Pharmacol
. 1997 Jul;
52(1):63-8.
PMID: 9224813
9-(2-phosphonylmethoxyethyl)guanine (PMEG) is an acyclic nucleoside phosphonate derivative that has demonstrated significant anticancer activity in a number of in vitro and in vivo animal model systems. In this study, we...
5.
Francis C, Connelly M
Cytometry
. 1996 Sep;
25(1):58-70.
PMID: 8875055
Fixation/permeabilization methods used for the detection of intracellular antigens by flow cytometry often result in the destruction of cellular morphology and surface immunoreactivity, properties useful in flow cytometry for the...
6.
Robbins B, Greenhaw J, Connelly M, Fridland A
Antimicrob Agents Chemother
. 1995 Oct;
39(10):2304-8.
PMID: 8619586
9-(2-Phosphonylmethoxyethyl)adenine (PMEA), the acyclic phosphonate analog of adenine monophosphate, is a promising antiviral drug with activity against herpesviruses, Epstein-Barr virus, and retroviruses, including the human immunodeficiency virus. In order to...
7.
Connelly M, Knight M, Giorgi J, Kagan J, Landay A, Parker J, et al.
Cytometry
. 1995 Sep;
22(3):200-10.
PMID: 8556951
The Ortho CytoronAbsolute is a flow cytometer designed to provide direct absolute counts of lymphocytes and their subsets from a single instrument. This study was designed to determine the performance...
8.
Aduma P, Connelly M, Srinivas R, Fridland A
Mol Pharmacol
. 1995 Apr;
47(4):816-22.
PMID: 7723743
The acyclic nucleoside phosphonates (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC), (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA), and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) inhibited herpes simplex virus-1 replication in Vero cells, and the IC50 values ranged from 4 microM (for HPMPC and...
9.
Mercolino T, Connelly M, Meyer E, Knight M, Parker J, Stelzer G, et al.
Cytometry
. 1995 Mar;
22(1):48-59.
PMID: 7587734
We describe a method to obtain results for immune status monitoring that uses a three-test panel, comprised of isotype control and 2 specific Mab tests (CD4/CD8/CD3 and CD16/CD19/CD3), in conjunction...
10.
Robbins B, Connelly M, Marshall D, Srinivas R, Fridland A
Mol Pharmacol
. 1995 Feb;
47(2):391-7.
PMID: 7870049
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a new antiviral agent with activity against herpes viruses and retroviruses, including human immunodeficiency virus, but its metabolism and mechanism of action remain unclear. We have isolated...