M C Barton
Overview
Explore the profile of M C Barton including associated specialties, affiliations and a list of published articles.
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24
Citations
434
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Recent Articles
1.
Li J, Xi Y, McCarthy R, Stratton S, Zou W, Li W, et al.
Oncogene
. 2017 Jan;
36(21):2991-3001.
PMID: 28068325
Histone methyl transferase EZH2 (Enhancer of Zeste Homolog 2) is generally associated with H3K27 methylation and gene silencing, as a member of the polycomb repressor 2 (PRC2) complex. Immunoprecipitation and...
2.
Pathiraja T, Thakkar K, Jiang S, Stratton S, Liu Z, Gagea M, et al.
Oncogene
. 2014 Jul;
34(22):2836-45.
PMID: 25065590
Tripartite motif 24 protein (TRIM24) is a plant homeodomain/bromodomain histone reader, recently associated with poor overall survival of breast-cancer patients. At a molecular level, TRIM24 is a negative regulator of...
3.
Qian J, Steigerwald K, Combs K, Barton M, Groden J
Oncogene
. 2007 Feb;
26(33):4872-6.
PMID: 17297457
The adenomatous polyposis coli (APC) tumor suppressor is inactivated by mutation in most colorectal tumors. APC is a component of the Wnt signaling pathway and is best known for its...
4.
Ogden S, Lee K, Stratton S, Aronow B, Barton M
J Biol Chem
. 2001 Sep;
276(45):42057-62.
PMID: 11572852
Many of the functions ascribed to p53 tumor suppressor protein are mediated through transcription regulation. We have shown that p53 represses hepatic-specific alpha-fetoprotein (AFP) gene expression by direct interaction with...
5.
Barton M, Crowe A
Oncogene
. 2001 Jun;
20(24):3094-9.
PMID: 11420725
Polymerase accessibility to chromatin is a limiting step in both RNA and DNA synthesis. Unwinding DNA and nucleosomes during polymerase complex binding and processing likely requires priming by chromatin restructuring....
6.
Rockx D, Mason R, van Hoffen A, Barton M, Citterio E, Bregman D, et al.
Proc Natl Acad Sci U S A
. 2000 Sep;
97(19):10503-8.
PMID: 10973477
Cells from patients with Cockayne syndrome (CS) are hypersensitive to DNA-damaging agents and are unable to restore damage-inhibited RNA synthesis. On the basis of repair kinetics of different types of...
7.
Ogden S, Lee K, Barton M
J Biol Chem
. 2000 Jun;
275(36):27806-14.
PMID: 10842185
Chronic infection with hepatitis B virus (HBV) is associated with development of hepatocellular carcinoma (HCC). The exact mechanism by which chronic infection with HBV contributes to onset of HCC is...
8.
Crowe A, Piechan J, Sang L, Barton M
Mol Cell Biol
. 2000 May;
20(11):4169-80.
PMID: 10805758
Aberrant expression of developmentally silenced genes, characteristic of tumor cells and regenerating tissue, is highly correlated with increased cell proliferation. By modeling this process in vitro in synthetic nuclei, we...
9.
Kroll S, Paulding W, Schnell P, Barton M, Conaway J, Conaway R, et al.
J Biol Chem
. 1999 Oct;
274(42):30109-14.
PMID: 10514498
Rat pheochromocytoma (PC12) cells were stably transfected with either wild type or mutated human von Hippel-Lindau tumor suppressor protein (hpVHL). These proteins have opposing effects on regulating expression of the...
10.
Crowe A, Sang L, Li K, Lee K, Spear B, Barton M
J Biol Chem
. 1999 Aug;
274(35):25113-20.
PMID: 10455192
The alpha-fetoprotein gene (AFP) is tightly regulated at the tissue-specific level, with expression confined to endoderm-derived cells. We have reconstituted AFP transcription on chromatin-assembled DNA templates in vitro. Our studies...