M Bols
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Explore the profile of M Bols including associated specialties, affiliations and a list of published articles.
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24
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58
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Recent Articles
1.
Bols M
IDrugs
. 2005 Jul;
3(11):1323-4.
PMID: 16047252
The symposium was attended by experts of carbohydrate science and encompassed a wide spectrum of carbohydrate chemistry and biology. Data presented included novel methods of synthesizing carbohydrates, as well as...
2.
Ernholt B, Thomsen Ib B, Lohse A, Plesner I, Jensen K, Hazell R, et al.
Chemistry
. 2002 Apr;
6(2):278-87.
PMID: 11931107
For the first time the two enantiomeric forms of the glycosidase inhibitor 1-azafagomine have been synthesised starting from D- and L-xylose. D-Xylose was converted to the 2,3,5-tribenzylfuranose, which upon reductive...
3.
Hansen S, Plesner I, Bols M
Chembiochem
. 2002 Feb;
1(3):177-80.
PMID: 11828410
A new method for the determination of active-enzyme concentration of a glucosidase by using (13)C NMR spectroscopy is reported. The method consists of quantifying the binding between a (13)C-labelled, strong...
4.
Andersch J, Bols M
Chemistry
. 2001 Sep;
7(17):3744-7.
PMID: 11575775
Starting from D-arabinose the synthesis of the very strong glycosidase inhibitors isofagomine (2) and noeuromycin (3) was achieved in six and seven steps, respectively. Keystep in the reaction sequence is...
5.
Plesner I, Bulow A, Bols M
Anal Biochem
. 2001 Aug;
295(2):186-93.
PMID: 11488621
This paper is concerned with the determination of rate constants characterizing the binding and release of a slow binding inhibitor to and from an enzyme, here almond beta-glucosidase. We demonstrate...
6.
Liu H, Liang X, Sohoel H, Bulow A, Bols M
J Am Chem Soc
. 2001 Jul;
123(21):5116-7.
PMID: 11457350
No abstract available.
7.
Sondergaard K, Liang X, Bols M
Chemistry
. 2001 Jul;
7(11):2324-31.
PMID: 11446635
The 5-aza-6-deoxy analogue of castanospermine (+/-)-5a and its 1-epimer (+/-)-5b was synthesized. The synthesis started from the known compound 5-benzyloxy-7-hydroxyhepta-1,3-diene, which was protected and subjected to Diels-Alder reaction with 4-phenyl-1,2,4-triazoline-3,5-dione...
8.
Bulow A, Plesner I, Bols M
Biochim Biophys Acta
. 2001 May;
1545(1-2):207-15.
PMID: 11342046
The thermodynamic and activation energies of the slow inhibition of almond beta-glucosidase with a series of azasugars were determined. The inhibitors studied were isofagomine ((3R,4R,5R)-3,4-dihydroxy-5-hydroxymethylpiperidine, 1), isogalactofagomine ((3R,4S,5R)-3,4-dihydroxy-5-hydroxymethylpiperidine, 2), (-)-1-azafagomine...
9.
Goud G, Artsaenko O, Bols M, Sierks M
Biotechnol Prog
. 2001 Feb;
17(1):197-202.
PMID: 11170499
Carbohydrates serve as key receptor sites in various cellular events such as viral attachment, tumor formation, and tissue inflammation. A potential route to control these events is to manipulate targeted...
10.
Liang X, Lohse A, Bols M
J Org Chem
. 2000 Nov;
65(22):7432-7.
PMID: 11076600
A new chemoenzymatic synthesis of optically pure isogalactofagomine 2 starting from achiral starting materials is presented. Dimethyl 4-hydroxypyridine-3,5-dicarboxylate (7) was synthesized and converted to the corresponding saturated piperidine 8. Then...