M Akers
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Explore the profile of M Akers including associated specialties, affiliations and a list of published articles.
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14
Citations
858
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Recent Articles
1.
Lassegue B, Sorescu D, Szocs K, Yin Q, Akers M, Zhang Y, et al.
Circ Res
. 2001 May;
88(9):888-94.
PMID: 11348997
Emerging evidence indicates that reactive oxygen species are important regulators of vascular function. Although NAD(P)H oxidases have been implicated as major sources of superoxide in the vessel wall, the molecular...
2.
Zafari A, Ushio-Fukai M, Minieri C, Akers M, Lassegue B, Griendling K
Antioxid Redox Signal
. 2001 Mar;
1(2):167-79.
PMID: 11228745
Previously, we showed that angiotensin II stimulation of the NADH/NADPH oxidase is involved in hypertrophy of cultured vascular smooth muscle cells (VSMC). Here, we examine the pathways leading to oxidase...
3.
Ushio-Fukai M, Alexander R, Akers M, Yin Q, Fujio Y, Walsh K, et al.
J Biol Chem
. 1999 Jul;
274(32):22699-704.
PMID: 10428852
Angiotensin II, a hypertrophic/anti-apoptotic hormone, utilizes reactive oxygen species (ROS) as growth-related signaling molecules in vascular smooth muscle cells (VSMCs). Recently, the cell survival protein kinase Akt/protein kinase B (PKB)...
4.
Ushio-Fukai M, Alexander R, Akers M, Lyons P, Lassegue B, Griendling K
Mol Pharmacol
. 1999 Jan;
55(1):142-9.
PMID: 9882708
In cultured vascular smooth muscle cells (VSMCs), activation of phospholipase D (PLD) by angiotensin II (Ang II) represents a major source of sustained generation of second messengers. Understanding the molecular...
5.
Zafari A, Ushio-Fukai M, Akers M, Yin Q, Shah A, Harrison D, et al.
Hypertension
. 1998 Sep;
32(3):488-95.
PMID: 9740615
Recent evidence suggests that oxidative mechanisms may be involved in vascular smooth muscle cell (VSMC) hypertrophy. We previously showed that angiotensin II (Ang II) increases superoxide production by activating an...
6.
Ushio-Fukai M, Griendling K, Akers M, Lyons P, Alexander R
J Biol Chem
. 1998 Jul;
273(31):19772-7.
PMID: 9677408
Activation of phospholipase C (PLC) is one of the earliest events in angiotensin II (Ang II) type 1 (AT1) receptor (R)-mediated signal transduction in vascular smooth muscle cells (VSMCs). The...
7.
Ushio-Fukai M, Alexander R, Akers M, Griendling K
J Biol Chem
. 1998 Jun;
273(24):15022-9.
PMID: 9614110
Angiotensin II induces an oxidant stress-dependent hypertrophy in cultured vascular smooth muscle cells. To investigate the growth-related molecular targets of H2O2, we examined the redox sensitivity of agonist-stimulated activation of...
8.
Kai H, Alexander R, Ushio-Fukai M, Lyons P, Akers M, Griendling K
Biochem J
. 1998 Jun;
332 ( Pt 3):781-7.
PMID: 9620883
The vascular angiotensin II type 1 receptor (AT1AR) is a member of the G-protein-coupled receptor superfamily. We mapped the G-protein binding domains of the AT1AR using synthetic peptides selected from...
9.
Lassegue B, Alexander R, Clark M, Akers M, Griendling K
Biochem J
. 1993 Jun;
292 ( Pt 2):509-17.
PMID: 8503884
In cultured vascular smooth-muscle cells, angiotensin II produces a sustained formation of diacylglycerol (DG) and phosphatidic acid (PtdOH). Since the fatty acid composition of these molecules is likely to determine...
10.
Griendling K, Taubman M, Akers M, MENDLOWITZ M, Alexander R
J Biol Chem
. 1991 Aug;
266(23):15498-504.
PMID: 1651335
Phosphoinositide-specific phospholipase C (PLC) activities have been partially purified from cultured vascular smooth muscle cells and analyzed for substrate specificity, calcium and pH requirements, and molecular weight. The purification procedure...