M A Kelliher
Overview
Explore the profile of M A Kelliher including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
832
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Recent Articles
1.
Huiting L, Samaha Y, Zhang G, Roderick J, Li B, Anderson N, et al.
Leukemia
. 2018 May;
32(11):2339-2351.
PMID: 29743725
Despite the pivotal role of MYC in tumorigenesis, the mechanisms by which it promotes cancer aggressiveness remain incompletely understood. Here, we show that MYC transcriptionally upregulates the ubiquitin fusion degradation...
2.
Delgado-Martin C, Meyer L, Huang B, Shimano K, Zinter M, Nguyen J, et al.
Leukemia
. 2017 May;
31(12):2568-2576.
PMID: 28484265
While outcomes for children with T-cell acute lymphoblastic leukemia (T-ALL) have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid (GC) resistance is...
3.
Anderson N, Li D, Peng H, Laroche F, Mansour M, Gjini E, et al.
Leukemia
. 2016 Feb;
30(6):1365-74.
PMID: 26876595
Despite the pivotal role of MYC in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and many other cancers, the mechanisms underlying MYC-mediated tumorigenesis remain inadequately understood. Here we utilized...
4.
Reynolds C, Roderick J, LaBelle J, Bird G, Mathieu R, Bodaar K, et al.
Leukemia
. 2014 Feb;
28(9):1819-27.
PMID: 24552990
Treatment resistance in T-cell acute lymphoblastic leukemia (T-ALL) is associated with phosphatase and tensin homolog (PTEN) deletions and resultant phosphatidylinositol 3'-kinase (PI3K)-AKT pathway activation, as well as MYC overexpression, and...
5.
Draheim K, Hermance N, Yang Y, Arous E, Calvo J, Kelliher M
Oncogene
. 2010 Nov;
30(10):1252-60.
PMID: 21057528
The most common translocation in childhood T-cell acute lymphoblastic leukemia (T-ALL) involves the LMO2 locus, resulting in ectopic expression of the LMO2 gene in human thymocytes. The LMO2 gene was...
6.
Ramnarain D, Paulmurugan R, Park S, Mickey B, Asaithamby A, Saha D, et al.
Cell Death Differ
. 2007 Nov;
15(2):344-53.
PMID: 18007664
There is considerable interest in understanding how inflammatory responses influence cell proliferation and cancer. In this study, we show that the receptor-interacting protein (RIP1), a critical mediator of inflammation and...
7.
Shank-Calvo J, Draheim K, Bhasin M, Kelliher M
Oncogene
. 2006 Jan;
25(21):3023-31.
PMID: 16407836
Analysis of the INK4A/ARF locus in human T-ALL patients revealed frequent deletions in exon 2, the exon common to both p16(INK4A) and p14(ARF). Other studies have described selective deletion of...
8.
Kelliher M, Grimm S, Ishida Y, Kuo F, Stanger B, Leder P
Immunity
. 1998 Apr;
8(3):297-303.
PMID: 9529147
The death domain serine/threonine kinase RIP interacts with the death receptors Fas and tumor necrosis receptor 1 (TNFR1). In vitro, RIP stimulates apoptosis, SAPK/JNK, and NF-kappaB activation. To define the...
9.
Kelliher M, Seldin D, Leder P
EMBO J
. 1996 Oct;
15(19):5160-6.
PMID: 8895560
Ectopic activation of the TAL-1 gene in T lymphocytes occurs in the majority of cases of human T cell acute lymphoblastic leukemia (T-ALL), yet experiments to date have failed to...
10.
Kelliher M, Weckstein D, Knott A, Wortis H, Rosenberg N
Oncogene
. 1993 May;
8(5):1249-56.
PMID: 8479746
Mice reconstituted with BCR/ABL-infected 5-fluorouracil-treated bone marrow are considered a model system for human chronic myelogenous leukemia, a malignancy that arises in hematopoietic stem cells. These animals develop multiple types...