Lyubomir Vassilev
Overview
Explore the profile of Lyubomir Vassilev including associated specialties, affiliations and a list of published articles.
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7
Citations
304
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Recent Articles
1.
Zhang Z, Chu X, Liu J, Ding Q, Zhang J, Bartkovitz D, et al.
ACS Med Chem Lett
. 2014 Jun;
5(2):124-7.
PMID: 24900784
The development of small-molecule MDM2 inhibitors to restore dysfunctional p53 activities represents a novel approach for cancer treatment. In a previous communication, the efforts leading to the identification of a...
2.
Vu B, Wovkulich P, Pizzolato G, Lovey A, Ding Q, Jiang N, et al.
ACS Med Chem Lett
. 2014 Jun;
4(5):466-9.
PMID: 24900694
The p53 tumor suppressor is a potent transcription factor that plays a key role in the regulation of cellular responses to stress. It is controlled by its negative regulator MDM2,...
3.
Higgins B, Glenn K, Walz A, Tovar C, Filipovic Z, Hussain S, et al.
Clin Cancer Res
. 2014 May;
20(14):3742-52.
PMID: 24812409
Purpose: Antitumor clinical activity has been demonstrated for the MDM2 antagonist RG7112, but patient tolerability for the necessary daily dosing was poor. Here, utilizing RG7388, a second-generation nutlin with superior...
4.
Muret J, Hasmim M, Stasik I, Jalil A, Mallavialle A, Nanbakhsh A, et al.
PLoS One
. 2012 Jun;
7(6):e38808.
PMID: 22719951
Background: Isolated limb perfusion with TNF-α and melphalan is used with remarkable efficiency to treat unresectable limb sarcomas. Here we tested the ability of TNF-α to directly induce apoptosis of...
5.
Patterson D, Gao D, Trahan D, Johnson B, Ludwig A, Barbieri E, et al.
Angiogenesis
. 2011 Apr;
14(3):255-66.
PMID: 21484514
Neuroblastoma is the most common pediatric abdominal tumor and principally a p53 wild-type, highly vascular, aggressive tumor, with limited response to anti-VEGF therapies alone. MDM2 is a key inhibitor of...
6.
Vu B, Vassilev L
Curr Top Microbiol Immunol
. 2010 Nov;
348:151-72.
PMID: 21046355
The p53 tumor suppressor is controlled by MDM2, which binds p53 and negatively regulates its transcriptional activity and stability. Many tumors overproduce MDM2 to impair p53 function. Therefore, restoration of...
7.
Thompson T, Danilenko M, Vassilev L, Studzinski G
Cancer Biol Ther
. 2010 Jun;
10(4):344-50.
PMID: 20543580
Vitamin D derivatives can induce differentiation of human acute myeloid leukemia (AML) cells. Here, we investigated if the G₁ cell cycle block associated with monocytic differentiation is modulated by the...