Lyndsey C Bolanos
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Explore the profile of Lyndsey C Bolanos including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
357
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Recent Articles
1.
Hoyt S, Finocchio C, Croll E, Tawa G, Li H, Ma L, et al.
ACS Med Chem Lett
. 2024 Nov;
15(11):1843-1851.
PMID: 39563805
We report the discovery of an imidazopyridine series of IRAK1/4/pan-FLT3 kinase inhibitors. Optimization of this series has produced compound which displays potent and selective inhibition of IRAK1, IRAK4, FLT3, and...
2.
Matsui S, Ri C, Bolanos L, Choi K, Shibamiya A, Ishii A, et al.
Leukemia
. 2024 Apr;
38(5):1032-1045.
PMID: 38609495
TNF receptor associated factor 6 (TRAF6) is an E3 ubiquitin ligase that has been implicated in myeloid malignancies. Although altered TRAF6 expression is observed in human acute myeloid leukemia (AML),...
3.
Bennett J, Ishikawa C, Agarwal P, Yeung J, Sampson A, Uible E, et al.
Blood
. 2023 May;
142(11):989-1007.
PMID: 37172199
Dysregulation of innate immune signaling is a hallmark of hematologic malignancies. Recent therapeutic efforts to subvert aberrant innate immune signaling in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) have...
4.
Barreyro L, Sampson A, Ishikawa C, Hueneman K, Choi K, Pujato M, et al.
Sci Transl Med
. 2022 Mar;
14(635):eabb7695.
PMID: 35263148
Dysregulation of innate immune signaling pathways is implicated in various hematologic malignancies. However, these pathways have not been systematically examined in acute myeloid leukemia (AML). We report that AML hematopoietic...
5.
Muto T, Guillamot M, Yeung J, Fang J, Bennett J, Nadorp B, et al.
Cell Stem Cell
. 2022 Jan;
29(2):298-314.e9.
PMID: 35045331
Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of pre-leukemic cells that acquire specific mutations. Although individuals with CH are healthy, they are at an increased...
6.
Niederkorn M, Ishikawa C, Hueneman K, Bartram J, Stepanchick E, R Bennett J, et al.
Leukemia
. 2021 Sep;
36(2):438-451.
PMID: 34465865
Ubiquitin-specific peptidase 15 (USP15) is a deubiquitinating enzyme implicated in critical cellular and oncogenic processes. We report that USP15 mRNA and protein are overexpressed in human acute myeloid leukemia (AML)...
7.
Schieber M, Marinaccio C, Bolanos L, Haffey W, Greis K, Starczynowski D, et al.
Blood Cancer J
. 2020 Oct;
10(10):98.
PMID: 33024076
Myelodysplastic syndrome (MDS) is a heterogeneous myeloid malignancy characterized by blood cell morphological dysplasia, ineffective clonal hematopoiesis, and risk of transformation to secondary acute myeloid leukemia (sAML). A number of...
8.
Melgar K, Walker M, Jones L, Bolanos L, Hueneman K, Wunderlich M, et al.
Sci Transl Med
. 2019 Sep;
11(508).
PMID: 31484791
Targeted inhibitors to oncogenic kinases demonstrate encouraging clinical responses early in the treatment course; however, most patients will relapse because of target-dependent mechanisms that mitigate enzyme-inhibitor binding or through target-independent...
9.
Smith M, Choudhary G, Pellagatti A, Choi K, Bolanos L, Bhagat T, et al.
Nat Cell Biol
. 2019 Apr;
21(5):640-650.
PMID: 31011167
Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but the oncogenic changes due to these mutations have not been identified. Here a global analysis of...
10.
Fang J, Muto T, Kleppe M, Bolanos L, Hueneman K, Walker C, et al.
Cell Rep
. 2018 Feb;
22(5):1250-1262.
PMID: 29386112
Basal nuclear factor κB (NF-κB) activation is required for hematopoietic stem cell (HSC) homeostasis in the absence of inflammation; however, the upstream mediators of basal NF-κB signaling are less well...