Lyle Armstrong
Overview
Explore the profile of Lyle Armstrong including associated specialties, affiliations and a list of published articles.
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104
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3850
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Recent Articles
1.
Watson A, Queen R, Ferrandez-Peral L, Dorgau B, Collin J, Nelson A, et al.
Cell Death Dis
. 2025 Feb;
16(1):108.
PMID: 39971915
Stargardt disease is an inherited retinopathy affecting approximately 1:8000 individuals. It is characterised by biallelic variants in ABCA4 which encodes a vital protein for the recycling of retinaldehydes in the...
2.
Moya-Molina M, Dorgau B, Flood E, Letteboer S, Lorentzen E, Coxhead J, et al.
Cell Death Dis
. 2024 Oct;
15(10):721.
PMID: 39353897
Alternative splicing (AS) is a crucial mechanism contributing to proteomic diversity, which is highly regulated in tissue- and development-specific patterns. Retinal tissue exhibits one of the highest levels of AS....
3.
Tsikandelova R, Galo E, Cerniauskas E, Hallam D, Georgiou M, Cerna-Chavez R, et al.
Stem Cell Reports
. 2024 Jul;
19(8):1107-1121.
PMID: 38964324
Biallelic mutations in DRAM2 lead to an autosomal recessive cone-rod dystrophy known as CORD21, which typically presents between the third and sixth decades of life. Although DRAM2 localizes to the...
4.
Roguski A, Needham N, MacGillivray T, Martinovic J, Dhillon B, Riha R, et al.
Wellcome Open Res
. 2024 May;
9:64.
PMID: 38716042
Many people with bipolar disorder have disrupted circadian rhythms. This means that the timing of sleep and wake activities becomes out-of-sync with the standard 24-hour cycle. Circadian rhythms are strongly...
5.
Chandrasekaran V, Wellens S, Bourguignon A, Djidrovski I, Fransen L, Ghosh S, et al.
Toxicol In Vitro
. 2024 Apr;
98:105826.
PMID: 38615723
Human induced pluripotent stem cells (iPSC) have the potential to produce desired target cell types in vitro and allow for the high-throughput screening of drugs/chemicals at population level thereby minimising...
6.
Atkinson R, Georgiou M, Yang C, Szymanska K, Lahat A, Vasconcelos E, et al.
Nat Commun
. 2024 Apr;
15(1):3138.
PMID: 38605034
The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity...
7.
Dorgau B, Collin J, Rozanska A, Boczonadi V, Moya-Molina M, Unsworth A, et al.
iScience
. 2024 Mar;
27(4):109397.
PMID: 38510120
Molecular information on the early stages of human retinal development remains scarce due to limitations in obtaining early human eye samples. Pluripotent stem cell-derived retinal organoids (ROs) provide an unprecedented...
8.
Kurzawa-Akanbi M, Tzoumas N, Corral-Serrano J, Guarascio R, Steel D, Cheetham M, et al.
Prog Retin Eye Res
. 2024 Feb;
100:101248.
PMID: 38369182
Blindness poses a growing global challenge, with approximately 26% of cases attributed to degenerative retinal diseases. While gene therapy, optogenetic tools, photosensitive switches, and retinal prostheses offer hope for vision...
9.
Armstrong L, Lako M
Front Cell Dev Biol
. 2023 Nov;
11:1298956.
PMID: 37908641
No abstract available.
10.
Chichagova V, Georgiou M, Carter M, Dorgau B, Hilgen G, Collin J, et al.
J Cell Mol Med
. 2023 Jan;
27(3):435-445.
PMID: 36644817
Microglia are the primary resident immune cells in the retina. They regulate neuronal survival and synaptic pruning making them essential for normal development. Following injury, they mediate adaptive responses and...