Lyle Armstrong
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Explore the profile of Lyle Armstrong including associated specialties, affiliations and a list of published articles.
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104
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Recent Articles
11.
Kurzawa-Akanbi M, Whitfield P, Burte F, Bertelli P, Pathak V, Doherty M, et al.
J Extracell Vesicles
. 2022 Dec;
11(12):e12295.
PMID: 36544284
Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we...
12.
Jackson R, Hatton C, Spegarova J, Georgiou M, Collin J, Stephenson E, et al.
Stem Cell Reports
. 2022 Jun;
17(7):1699-1713.
PMID: 35750043
Conjunctival epithelial cells, which express viral-entry receptors angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine type 2 (TMPRSS2), constitute the largest exposed epithelium of the ocular surface tissue and may...
13.
Djidrovski I, Georgiou M, Tasinato E, Leonard M, van den Bor J, Lako M, et al.
Cell Biol Toxicol
. 2022 May;
39(1):1-18.
PMID: 35641671
The airway epithelium represents the main barrier between inhaled air and the tissues of the respiratory tract and is therefore an important point of contact with xenobiotic substances into the...
14.
Rozanska A, Cerna-Chavez R, Queen R, Collin J, Zerti D, Dorgau B, et al.
Stem Cells Transl Med
. 2022 Mar;
11(4):415-433.
PMID: 35325233
Retinoblastoma (Rb) is a childhood cancer of the developing retina, accounting for up to 17% of all tumors in infancy. To gain insights into the transcriptional events of cell state...
15.
Dorgau B, Georgiou M, Chaudhary A, Moya-Molina M, Collin J, Queen R, et al.
Stem Cells Transl Med
. 2022 Mar;
11(2):159-177.
PMID: 35298655
Retinal drug toxicity screening is essential for the development of safe treatment strategies for a large number of diseases. To this end, retinal organoids derived from human pluripotent stem cells...
16.
Georgiou M, Yang C, Atkinson R, Pan K, Buskin A, Moya Molina M, et al.
Clin Transl Med
. 2022 Mar;
12(3):e759.
PMID: 35297555
Introduction: Mutations in pre-mRNA processing factor 31 (PRPF31), a core protein of the spliceosomal tri-snRNP complex, cause autosomal-dominant retinitis pigmentosa (adRP). It has remained an enigma why mutations in ubiquitously...
17.
Yang C, Georgiou M, Atkinson R, Collin J, Al-Aama J, Nagaraja-Grellscheid S, et al.
Front Cell Dev Biol
. 2021 Aug;
9:700276.
PMID: 34395430
Retinitis pigmentosa (RP) is the most common inherited retinal disease characterized by progressive degeneration of photoreceptors and/or retinal pigment epithelium that eventually results in blindness. Mutations in pre-mRNA processing factors...
18.
Djidrovski I, Georgiou M, Hughes G, Patterson E, Casas-Sanchez A, Pennington S, et al.
Stem Cells
. 2021 Jun;
39(10):1310-1321.
PMID: 34152044
As one of the primary points of entry of xenobiotic substances and infectious agents into the body, the lungs are subject to a range of dysfunctions and diseases that together...
19.
Collin J, Queen R, Zerti D, Bojic S, Dorgau B, Moyse N, et al.
Ocul Surf
. 2021 Apr;
21:279-298.
PMID: 33865984
Purpose: Single cell (sc) analyses of key embryonic, fetal and adult stages were performed to generate a comprehensive single cell atlas of all the corneal and adjacent conjunctival cell types...
20.
Armstrong L, Collin J, Mostafa I, Queen R, Figueiredo F, Lako M
Stem Cells Transl Med
. 2021 Mar;
10(7):976-986.
PMID: 33710758
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged in December 2019 and spread quickly causing the coronavirus disease 2019 (COVID-19) pandemic. Recent single cell RNA-Seq analyses have shown the...