Lydia N Caro
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Explore the profile of Lydia N Caro including associated specialties, affiliations and a list of published articles.
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11
Citations
551
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Recent Articles
1.
Loyau J, Monney T, Montefiori M, Bokhovchuk F, Streuli J, Blackburn M, et al.
MAbs
. 2025 Jan;
17(1):2457471.
PMID: 39882744
ISB 1442 is a bispecific biparatopic antibody in clinical development to treat hematological malignancies. It consists of two adjacent anti-CD38 arms targeting non-overlapping epitopes that preferentially drive binding to tumor...
2.
Carretero-Iglesia L, Hall O, Berret J, Pais D, Estoppey C, Chimen M, et al.
Nat Cancer
. 2024 Sep;
5(10):1494-1514.
PMID: 39261676
Despite recent advances in immunotherapies targeting single tumor-associated antigens, patients with multiple myeloma eventually relapse. ISB 2001 is a CD3 T cell engager (TCE) co-targeting BCMA and CD38 designed to...
3.
Van Eps N, Altenbach C, Caro L, Latorraca N, Hollingsworth S, Dror R, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(10):2383-2388.
PMID: 29463720
More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered. Upon light-induced changes in ligand-receptor interaction, movement of specific...
4.
Van Eps N, Caro L, Morizumi T, Kusnetzow A, Szczepek M, Hofmann K, et al.
Proc Natl Acad Sci U S A
. 2017 Apr;
114(16):E3268-E3275.
PMID: 28373559
Conformational equilibria of G-protein-coupled receptors (GPCRs) are intimately involved in intracellular signaling. Here conformational substates of the GPCR rhodopsin are investigated in micelles of dodecyl maltoside (DDM) and in phospholipid...
5.
Moreau C, Revilloud J, Caro L, Dupuis J, Trouchet A, Estrada-Mondragon A, et al.
Sci Rep
. 2017 Feb;
7:41154.
PMID: 28145461
Ligand-gated ion channels enable intercellular transmission of action potential through synapses by transducing biochemical messengers into electrical signal. We designed artificial ligand-gated ion channels by coupling G protein-coupled receptors to...
6.
Ploier B, Caro L, Morizumi T, Pandey K, Pearring J, Goren M, et al.
Nat Commun
. 2016 Oct;
7:12832.
PMID: 27694816
Retinitis pigmentosa (RP) is a blinding disease often associated with mutations in rhodopsin, a light-sensing G protein-coupled receptor and phospholipid scramblase. Most RP-associated mutations affect rhodopsin's activity or transport to...
7.
Kang Y, Zhou X, Gao X, He Y, Liu W, Ishchenko A, et al.
Nature
. 2015 Jul;
523(7562):561-7.
PMID: 26200343
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-protein-independent pathways. Here we report the crystal...
8.
Van Eps N, Caro L, Morizumi T, Ernst O
Photochem Photobiol Sci
. 2015 Jul;
14(9):1586-97.
PMID: 26140679
Electron paramagnetic resonance (EPR) spectroscopy, together with spin labeling techniques, has played a major role in the characterization of rhodopsin, the photoreceptor protein and G protein-coupled receptor (GPCR) in rod...
9.
Moreau C, Niescierowicz K, Caro L, Revilloud J, Vivaudou M
Methods Enzymol
. 2015 Apr;
556:425-54.
PMID: 25857794
Ion channel-coupled receptor (ICCR) is a recent technology based on the fusion of G protein-coupled receptors (GPCRs) to an ion channel. Binding of ligands on the GPCR triggers conformational changes...
10.
Caro L, Li Z, Balo A, Van Eps N, Rini J, Ernst O
Methods Enzymol
. 2015 Apr;
556:307-30.
PMID: 25857788
Rhodopsin is a class A G protein-coupled receptor (GPCR) that provides important insights into the structure and function of the GPCR superfamily. Bovine rhodopsin is widely used as a model...