Luqi Duan
Overview
Explore the profile of Luqi Duan including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
324
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0
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Recent Articles
1.
Griffin J, Chen X, Duan L, Mu Q, Ho R
PLoS One
. 2024 Mar;
19(3):e0300723.
PMID: 38547077
Preclinical models of cancer are vital for assessing and predicting efficacies and toxicities of novel treatments prior to testing in human subjects. Current pancreatic tumor models exhibit variable growth rates,...
2.
Umbaugh D, Soder R, Nguyen N, Adelusi O, Robarts D, Woolbright B, et al.
Arch Toxicol
. 2022 Sep;
96(12):3315-3329.
PMID: 36057886
The persistence of hepatotoxicity induced by N-acetyl-para-aminophenol (Acetaminophen or Paracetamol, abbreviated as APAP) as the most common cause of acute liver failure in the United States, despite the availability of...
3.
Duan L, Sanchez-Guerrero G, Jaeschke H, Ramachandran A
Food Chem Toxicol
. 2022 Mar;
163:112911.
PMID: 35292334
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the USA. The short therapeutic window of the current antidote, N-acetylcysteine (NAC) highlights the need for novel...
4.
Jaeschke H, Duan L, Nguyen N, Ramachandran A
Liver Res
. 2020 Jul;
3(3-4):150-156.
PMID: 32655976
Liver injury and acute liver failure caused by acetaminophen (APAP) overdose is the clinically most important drug toxicity in western countries. Mechanistic investigations have revealed a central role of mitochondria...
5.
Duan L, Woolbright B, Jaeschke H, Ramachandran A
Toxicol Sci
. 2020 Mar;
175(2):168-181.
PMID: 32207522
Acetaminophen (APAP) overdose-induced acute liver failure is an important clinical problem in the United States and the current antidote N-acetylcysteine, has a short early therapeutic window. Since most patients present...
6.
Duan L, Ramachandran A, Akakpo J, Woolbright B, Zhang Y, Jaeschke H
Toxicol Appl Pharmacol
. 2019 Dec;
387:114849.
PMID: 31809757
Though mitochondrial oxidant stress plays a critical role in the progression of acetaminophen (APAP) overdose-induced liver damage, the influence of mitochondrial bioenergetics on this is not well characterized. This is...
7.
Akakpo J, Ramachandran A, Duan L, Schaich M, Jaeschke M, Freudenthal B, et al.
Toxicol Sci
. 2019 Mar;
170(1):57-68.
PMID: 30903181
Acetaminophen (APAP) overdose is the most common cause of hepatotoxicity and acute liver failure in the United States and many western countries. However, the only clinically approved antidote, N-acetylcysteine, has...
8.
Ramachandran A, Visschers R, Duan L, Akakpo J, Jaeschke H
J Clin Transl Res
. 2019 Mar;
4(1):75-100.
PMID: 30873497
Mitochondria are critical cellular organelles for energy generation and are now also recognized as playing important roles in cellular signaling. Their central role in energy metabolism, as well as their...
9.
Duan L, Ramachandran A, Akakpo J, Weemhoff J, Curry S, Jaeschke H
Toxicol Lett
. 2018 Nov;
301:125-132.
PMID: 30447259
Formation of acetaminophen (APAP) protein adducts are a critical feature of APAP hepatotoxicity, and circulating protein adducts have recently been utilized in bioassays for identification of APAP overdose in humans....
10.
Jaeschke H, Duan L, Akakpo J, Farhood A, Ramachandran A
Food Chem Toxicol
. 2018 Jun;
118:709-718.
PMID: 29920288
Although necrosis is recognized as the main mode of cell death induced by acetaminophen (APAP) overdose in animals and humans, more recently an increasing number of publications, especially in the...