Lunbin Deng
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Explore the profile of Lunbin Deng including associated specialties, affiliations and a list of published articles.
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20
Citations
1206
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Recent Articles
11.
Kaeser P, Deng L, Fan M, Sudhof T
Proc Natl Acad Sci U S A
. 2012 Jul;
109(29):11830-5.
PMID: 22753485
Tight coupling of Ca(2+) channels to the presynaptic active zone is critical for fast synchronous neurotransmitter release. RIMs are multidomain proteins that tether Ca(2+) channels to active zones, dock and...
12.
Deng L, Kaeser P, Xu W, Sudhof T
Neuron
. 2011 Jan;
69(2):317-31.
PMID: 21262469
At a synapse, the presynaptic active zone mediates synaptic vesicle exocytosis. RIM proteins are active zone scaffolding molecules that--among others--mediate vesicle priming and directly or indirectly interact with most other...
13.
Kaeser P, Deng L, Wang Y, Dulubova I, Liu X, Rizo J, et al.
Cell
. 2011 Jan;
144(2):282-95.
PMID: 21241895
At a synapse, fast synchronous neurotransmitter release requires localization of Ca(2+) channels to presynaptic active zones. How Ca(2+) channels are recruited to active zones, however, remains unknown. Using unbiased yeast...
14.
Kaeser P, Deng L, Chavez A, Liu X, Castillo P, Sudhof T
Neuron
. 2009 Oct;
64(2):227-39.
PMID: 19874790
The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a...
15.
Kaeser P, Kwon H, Chiu C, Deng L, Castillo P, Sudhof T
J Neurosci
. 2008 Dec;
28(50):13435-47.
PMID: 19074017
At a synapse, presynaptic terminals form a specialized area of the plasma membrane called the active zone that mediates neurotransmitter release. RIM1alpha is a multidomain protein that constitutes a central...
16.
Deng L, Yao J, Fang C, Dong N, Luscher B, Chen G
J Neurosci
. 2007 Oct;
27(40):10860-9.
PMID: 17913919
Sequential formation of GABAergic and glutamatergic synapses is thought to be crucial for constructing the stereotypic neural networks during brain development. However, why GABAergic synapses are formed earlier than glutamatergic...
17.
Fang C, Deng L, Keller C, Fukata M, Fukata Y, Chen G, et al.
J Neurosci
. 2006 Dec;
26(49):12758-68.
PMID: 17151279
Golgi-specific DHHC (Asp-His-His-Cys) zinc finger protein (GODZ) is a DHHC family palmitoyl acyltransferase that is implicated in palmitoylation and regulated trafficking of diverse substrates that function either at inhibitory or...
18.
Tu H, Deng L, Sun Q, Yao L, Han J, Wan Y
J Neurosci Res
. 2004 May;
76(5):713-22.
PMID: 15139030
The large, medium-sized, and small neurons of the dorsal root ganglion (DRG) have different functions in the processing of various senses. Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN) contribute greatly to neuronal...
19.
Deng L, Chen G
Proc Natl Acad Sci U S A
. 2003 Oct;
100(22):13025-9.
PMID: 14534329
Ionotropic glutamate and gamma-aminobutyric acid type A (GABAA) receptors mediate critical excitatory and inhibitory actions in the brain. Cyclothiazide (CTZ) is well known for its effect of enhancing glutamatergic transmission...
20.
Chen Y, Deng L, Maeno-Hikichi Y, Lai M, Chang S, Chen G, et al.
Cell
. 2003 Oct;
115(1):37-48.
PMID: 14532001
A tight balance between synaptic vesicle exocytosis and endocytosis is fundamental to maintaining synaptic structure and function. Calcium influx through voltage-gated Ca2+ channels is crucial in regulating synaptic vesicle exocytosis....