Luke Jostins
Overview
Explore the profile of Luke Jostins including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
40
Citations
9414
Followers
0
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Zhou D, Borsa M, Puleston D, Zellner S, Capera J, Sanderson S, et al.
Nat Commun
. 2022 Sep;
13(1):5174.
PMID: 36055998
CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic immune responses. It is known that CD4+ T cell proliferation relies on autophagy, but identification...
2.
Bonfiglio F, Liu X, Smillie C, Pandit A, Kurilshikov A, Bacigalupe R, et al.
Cell Genom
. 2021 Dec;
1(3):None.
PMID: 34957435
Gut dysmotility is associated with constipation, diarrhea, and functional gastrointestinal disorders like irritable bowel syndrome (IBS), although its molecular underpinnings are poorly characterized. We studied stool frequency (defined by the...
3.
Bolton C, Smillie C, Pandey S, Elmentaite R, Wei G, Argmann C, et al.
Gastroenterology
. 2021 Nov;
162(3):859-876.
PMID: 34780721
Background & Aims: Monogenic forms of inflammatory bowel disease (IBD) illustrate the essential roles of individual genes in pathways and networks safeguarding immune tolerance and gut homeostasis. Methods: To build...
4.
Eijsbouts C, Zheng T, Kennedy N, Bonfiglio F, Anderson C, Moutsianas L, et al.
Nat Genet
. 2021 Nov;
53(11):1543-1552.
PMID: 34741163
Irritable bowel syndrome (IBS) results from disordered brain-gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified...
5.
von Loga I, Miotla-Zarebska J, Huang Y, Williams R, Jostins L, Vincent T
Osteoarthr Cartil Open
. 2020 Dec;
2(4):100101.
PMID: 33381766
Objective: Evoked responses following mechanical or thermal stimulation are typically used to assess pain behaviour in murine osteoarthritis (OA). However, there is no consensus on how best to measure spontaneous...
6.
Glinos D, Soskic B, Williams C, Kennedy A, Jostins L, Sansom D, et al.
Genes Immun
. 2020 Nov;
21(6-8):390-408.
PMID: 33223527
T-cell activation is a critical driver of immune responses. The CD28 costimulation is an essential regulator of CD4 T-cell responses, however, its relative importance in naive and memory T cells...
7.
Graphical Model Selection for Gaussian Conditional Random Fields in the Presence of Latent Variables
Frot B, Jostins L, McVean G
J Am Stat Assoc
. 2019 Aug;
114(526):723-734.
PMID: 31391793
We consider the problem of learning a conditional Gaussian graphical model in the presence of latent variables. Building on recent advances in this field, we suggest a method that decomposes...
8.
Rivas M, Avila B, Koskela J, Huang H, Stevens C, Pirinen M, et al.
PLoS Genet
. 2019 May;
15(5):e1008190.
PMID: 31145742
[This corrects the article DOI: 10.1371/journal.pgen.1007329.].
9.
Trochet H, Pirinen M, Band G, Jostins L, McVean G, Spencer C
Genet Epidemiol
. 2019 Mar;
43(5):532-547.
PMID: 30920090
Genome-wide association studies (GWAS) are a powerful tool for understanding the genetic basis of diseases and traits, but most studies have been conducted in isolation, with a focus on either...
10.
von Loga I, El-Turabi A, Jostins L, Miotla-Zarebska J, Mackay-Alderson J, Zeltins A, et al.
Ann Rheum Dis
. 2019 Mar;
78(5):672-675.
PMID: 30862648
Objectives: Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis (OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a...